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Tbio
PYCR3
Pyrroline-5-carboxylate reductase 3

Protein Summary
Description
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433751
  • ENSP00000404493
  • ENSG00000104524
  • ENST00000495276
  • ENSP00000480945
  • ENST00000631620
  • ENSP00000488877
  • ENSG00000276657
  • ENST00000632107
  • ENSP00000488371

Symbol
  • PYCRL
  • PYCRL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
PCMT1
Tbio
Family:  Enzyme
Novelty:  0.01414946
p_int:  0.970665953
p_ni:  0.029334047
Score:  0.205
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.935848441
p_ni:  0.064151559
Data Source:  BioPlex
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
p_int:  0.925693268
p_ni:  0.074306732
Score:  0.987
Data Source:  BioPlex,STRINGDB
PYCR2
Tbio
Family:  Enzyme
Novelty:  0.05660996
p_int:  0.891045026
p_ni:  0.108954974
Score:  0.967
Data Source:  BioPlex,STRINGDB
ALDH4A1
Tbio
Family:  Enzyme
Novelty:  0.01316227
Score:  0.954
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.933
Data Source:  STRINGDB
LAP3
Tchem
Family:  Enzyme
Novelty:  0.00327467
Score:  0.908
Data Source:  STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
Score:  0.903
Data Source:  STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
Score:  0.901
Data Source:  STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Arginine and proline metabolism
KEGG
Metabolic pathways
KEGG
Biosynthesis of amino acids
Name
Explore in Pharos
Explore in Source
Arginine and proline metabolism
Metabolic pathways
Biosynthesis of amino acids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
92.3
red blood cell distribution width
3
2
3
92.3
metabolite measurement
1
1
1
82.8
metabolite measurement
1
1
1
82.8
C-reactive protein measurement
2
2
2
75.9
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
92.3
red blood cell distribution width
3
92.3
metabolite measurement
1
82.8
metabolite measurement
1
82.8
C-reactive protein measurement
2
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrroline-5-carboxylate reductase 3
VGNC:50318
472886
Macaque
pyrroline-5-carboxylate reductase 3
709285
Mouse
MGI:1913444
66194
Rat
RGD:1309115
300035
Dog
pyrroline-5-carboxylate reductase 3
VGNC:45224
482079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrroline-5-carboxylate reductase 3
Macaque
pyrroline-5-carboxylate reductase 3
Mouse
Rat
Dog
pyrroline-5-carboxylate reductase 3
Publication Statistics
PubMed Score 8.53
PubMed score by year
PubTator Score 0.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title