Tbio LACTB2 Endoribonuclease LACTB2

Protein Summary

Description

Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

Uniprot Accession IDs

• Q53H82
• A8K2D6
• Q9Y392

Gene Name

• LACTB2

Ensembl ID

• ENST00000276590
• ENSP00000276590
• ENSG00000147592
• ENST00000522447
• ENSP00000428801

Symbol

• CGI-83

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
transcription factor binding site profile	0.87
histone modification site profile	0.71
PubMedID	0.69
cell line	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Endoribonuclease Lactb2

Protein / Defense/immunity Protein / Endoribonuclease Lactb2

DTO Classes

Protein / Enzyme / Hydrolase / Endoribonuclease Lactb2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.58   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.58   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0