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Tbio
AKIRIN2
Akirin-2

Protein Summary
Description
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257787
  • ENSP00000257787
  • ENSG00000135334

Symbol
  • C6orf166
  • FBI1
  • C6orf166
  • dJ486L4.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
virus perturbation
0.9
biological process
0.84
gene perturbation
0.81
small molecule perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (68)
1 – 10 of 68
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.999999711
p_ni:  2.89e-7
Score:  0.77
Data Source:  BioPlex,STRINGDB
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
p_int:  0.999999195
p_ni:  8.05e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.999998589
p_ni:  0.000001408
p_wrong:  3e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.999996669
p_ni:  0.000002891
p_wrong:  4.4e-7
Data Source:  BioPlex
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999953293
p_ni:  0.000046707
Score:  0.254
Data Source:  BioPlex,STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.999805218
p_ni:  0.00002939
p_wrong:  0.000165392
Data Source:  BioPlex
SPG21
Tbio
Family:  Enzyme
Novelty:  0.07929043
p_int:  0.999786635
p_ni:  0.000005738
p_wrong:  0.000207627
Score:  0.364
Data Source:  BioPlex,STRINGDB
AKIRIN1
Tbio
Novelty:  0.16318877
p_int:  0.999427159
p_ni:  1.3e-8
p_wrong:  0.000572828
Score:  0.87
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.999267997
p_ni:  0.000732003
Data Source:  BioPlex
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.997991162
p_ni:  0.002008838
Data Source:  BioPlex
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
akirin 2
VGNC:2638
100612493
Macaque
akirin 2
700914
Mouse
MGI:1889364
433693
Rat
RGD:1307791
297968
Dog
akirin 2
VGNC:37766
485222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
akirin 2
Macaque
akirin 2
Mouse
Rat
Dog
akirin 2
Publication Statistics
PubMed Score 30.30
PubMed score by year
PubTator Score 6.11
PubTator score by year