Tbio AKIRIN2 Akirin-2

Protein Summary

Description

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).

Uniprot Accession IDs

• Q53H80
• Q9BQB1

Gene Name

• AKIRIN2

Ensembl ID

• ENST00000257787
• ENSP00000257787
• ENSG00000135334

Symbol

• C6orf166
• FBI1
• C6orf166
• dJ486L4.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
virus perturbation	0.9
biological process	0.84
gene perturbation	0.81
small molecule perturbation	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.03   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.03   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0