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Tbio
PLA1A
Phospholipase A1 member A

Protein Summary
Description
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273371
  • ENSP00000273371
  • ENSG00000144837
  • ENST00000488919
  • ENSP00000420625
  • ENST00000495992
  • ENSP00000417326

Symbol
  • NMD
  • PSPLA1
  • PSPLA1
  • PS-PLA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
metabolite
0.61
tissue sample
0.61
PubMedID
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.34   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.34   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
DNLZ
Tdark
Novelty:  0.10113346
p_int:  0.927863108
p_ni:  0.072109737
p_wrong:  0.000027155
Score:  0.277
Data Source:  BioPlex,STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
Score:  0.756
Data Source:  STRINGDB
ABT1
Tbio
Novelty:  0.05236553
Score:  0.752
Data Source:  STRINGDB
POU2F3
Tbio
Family:  TF
Novelty:  0.00233655
Score:  0.72
Data Source:  STRINGDB
GTF3C1
Tbio
Novelty:  0.00580303
Score:  0.641
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.609
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.609
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.582
Data Source:  STRINGDB
ZNF618
Tdark
Novelty:  0.43589506
Score:  0.524
Data Source:  STRINGDB
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
Score:  0.478
Data Source:  STRINGDB
Pathways (27)
Acyl chain remodelling of PS (R-HSA-1482801)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
92.6
3
3
0
1.2
82.3
primary biliary cirrhosis
3
2
0
1.4
75.4
2
2
0
1.3
64.3
Thyroid preparation use measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92.6
0
1.2
82.3
primary biliary cirrhosis
0
1.4
75.4
0
1.3
64.3
Thyroid preparation use measurement
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A1 member A
VGNC:2507
470894
Macaque
phospholipase A1 member A
712705
Mouse
MGI:1934677
85031
Rat
RGD:621261
85311
Dog
phospholipase A1 member A
VGNC:44619
100686158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A1 member A
Macaque
phospholipase A1 member A
Mouse
Rat
Dog
phospholipase A1 member A
Publication Statistics
PubMed Score 65.34
PubMed score by year
PubTator Score 14.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title