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Tbio
TRMT12
tRNA wybutosine-synthesizing protein 2 homolog

Protein Summary
Description
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328599
  • ENSP00000329858
  • ENSG00000183665

Symbol
  • TRM12
  • TYW2
  • TYW2
  • TRM12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
transcription factor binding site profile
0.78
tissue sample
0.69
gene perturbation
0.65
cellular component
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.9
14.2
traffic air pollution measurement
1
1
0
5.9
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.9
14.2
traffic air pollution measurement
0
5.9
14.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tRNA methyltransferase 12 homolog
705848
Mouse
MGI:1915510
68260
Rat
RGD:1307127
314999
Dog
tRNA methyltransferase 12 homolog
VGNC:47856
609411
Horse
tRNA methyltransferase 12 homolog
VGNC:24537
100067346
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tRNA methyltransferase 12 homolog
Mouse
Rat
Dog
tRNA methyltransferase 12 homolog
Horse
tRNA methyltransferase 12 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q53H54-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Synthesis of wybutosine at G37 of tRNA(Phe)
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Synthesis of wybutosine at G37 of tRNA(Phe)
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (69)
1 – 10 of 69
ZNF556
Tdark
Family:  TF
Novelty:  3.19575048
p_int:  0.999999995
p_ni:  5e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.918792585
p_ni:  0.081207415
Data Source:  BioPlex
HSPA4
Tbio
Novelty:  0.00009122
p_int:  0.862272289
p_ni:  0.137727711
Score:  0.348
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.813498833
p_ni:  0.186501167
Score:  0.157
Data Source:  BioPlex,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
Score:  0.964
Data Source:  STRINGDB
TRMT5
Tbio
Family:  Enzyme
Novelty:  0.02509765
Score:  0.92
Data Source:  STRINGDB
TYW1
Tbio
Family:  Enzyme
Novelty:  0.05117274
Score:  0.908
Data Source:  STRINGDB
TRMT112
Tbio
Family:  Enzyme
Novelty:  0.05451623
Score:  0.892
Data Source:  STRINGDB
LCMT2
Tbio
Family:  Enzyme
Novelty:  0.0388779
Score:  0.888
Data Source:  STRINGDB
TYW5
Tbio
Novelty:  0.1382439
Score:  0.874
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.70

PubMed score by year
PubTator Score  0.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer