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Tbio
SETMAR
Histone-lysine N-methyltransferase SETMAR

Protein Summary
Description
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358065
  • ENSP00000373354
  • ENSG00000170364
  • ENST00000425863
  • ENSP00000403145
  • ENST00000430981
  • ENSP00000403000

Symbol
  • Mar1
  • METNASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.89
protein domain
0.85
histone modification site profile
0.7
cell type or tissue
0.64


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.77   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.77   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
histone-lysine N-methyltransferase SETMAR
703880
Species
Name
OMA
EggNOG
Inparanoid
Macaque
histone-lysine N-methyltransferase SETMAR
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q53H47-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (88)
1 – 10 of 88
YJU2
Tdark
Novelty: 0.75647391
p_int: 1
Score: 0.219
Data Source: BioPlex,STRINGDB
IKZF3
Tbio
Family: TF
Novelty: 0.01038728
p_int: 0.999934726
p_ni: 0.000048971
p_wrong: 0.000016303
Score: 0.588
Data Source: BioPlex,STRINGDB
DOC2A
Tbio
Novelty: 0.07489914
p_int: 0.934085799
p_ni: 0.000135616
p_wrong: 0.065778585
Score: 0.214
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.89687617
p_ni: 0.10312383
Score: 0.16
Data Source: BioPlex,STRINGDB
SETX
Tbio
Family: Enzyme
Novelty: 0.00474094
p_int: 0.896130518
p_ni: 0.103869477
p_wrong: 5e-9
Score: 0.235
Data Source: BioPlex,STRINGDB
PCBP1
Tbio
Novelty: 0.00906713
p_int: 0.884589714
p_ni: 0.115410286
Score: 0.273
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
Score: 0.987
Data Source: STRINGDB
GPR180
Tbio
Novelty: 0.03378902
Score: 0.907
Data Source: STRINGDB
TMEM132D
Tbio
Novelty: 0.0637377
Score: 0.805
Data Source: STRINGDB
CHEK1
Tchem
Family: Kinase
Novelty: 0.00066843
Score: 0.766
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.77

PubMed score by year
PubTator Score  29.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer