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Tbio
SETMAR
Histone-lysine N-methyltransferase SETMAR

Protein Summary
Description
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358065
  • ENSP00000373354
  • ENSG00000170364
  • ENST00000425863
  • ENSP00000403145
  • ENST00000430981
  • ENSP00000403000

Symbol
  • Mar1
  • METNASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.89
protein domain
0.85
histone modification site profile
0.7
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.61   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.61   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
YJU2
Tdark
Novelty:  0.75647391
p_int:  1
Score:  0.219
Data Source:  BioPlex,STRINGDB
IKZF3
Tbio
Family:  TF
Novelty:  0.01038728
p_int:  0.999934726
p_ni:  0.000048971
p_wrong:  0.000016303
Score:  0.588
Data Source:  BioPlex,STRINGDB
DOC2A
Tbio
Novelty:  0.07489914
p_int:  0.934085799
p_ni:  0.000135616
p_wrong:  0.065778585
Score:  0.214
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.89687617
p_ni:  0.10312383
Score:  0.16
Data Source:  BioPlex,STRINGDB
SETX
Tbio
Family:  Enzyme
Novelty:  0.00474094
p_int:  0.896130518
p_ni:  0.103869477
p_wrong:  5e-9
Score:  0.235
Data Source:  BioPlex,STRINGDB
PCBP1
Tbio
Novelty:  0.00906713
p_int:  0.884589714
p_ni:  0.115410286
Score:  0.273
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.987
Data Source:  STRINGDB
GPR180
Tbio
Novelty:  0.03378902
Score:  0.907
Data Source:  STRINGDB
TMEM132D
Tbio
Novelty:  0.0637377
Score:  0.805
Data Source:  STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
Score:  0.766
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal vasculature measurement
1
1
1
30.2
brain measurement
1
1
0
5.9
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal vasculature measurement
1
30.2
brain measurement
0
5.9
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
histone-lysine N-methyltransferase SETMAR
703880
Species
Name
OMA
EggNOG
Inparanoid
Macaque
histone-lysine N-methyltransferase SETMAR
Publication Statistics
PubMed Score 55.61
PubMed score by year
PubTator Score 29.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title