Tbio USP39 U4/U6.U5 tri-snRNP-associated protein 2

Protein Summary

Description

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397).

Uniprot Accession IDs

• Q53GS9
• A8K086
• B3KM40
• B4DHT4
• D6W5L4
• G5E9H0
• Q6NX47
• Q96RK9
• Q9BV89
• Q9H381
• Q9P050
• Q9Y310

Gene Name

• USP39

Ensembl ID

• ENST00000323701
• ENSP00000312981
• ENSG00000168883
• ENST00000409470
• ENSP00000386864
• ENST00000409766
• ENSP00000386803
• ENST00000450066
• ENSP00000396133

Symbol

• 65K
• SAD1
• CGI-21
• HSPC332
• SNRNP65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
disease perturbation	0.9
transcription factor perturbation	0.84
ligand (protein) perturbation	0.83

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.03   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.03   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (257)

Explore Interacting Targets

1 – 10 of 257

• See Interactions on String-DB

PRPF4

Tchem

Novelty:  0.08229072

p_int:  0.961594902

p_ni:  0.038405098

Score:  0.983

Data Source:  BioPlex,STRINGDB

CDC5L

Tbio

Family:  TF

Novelty:  0.00663599

Score:  0.998

Data Source:  STRINGDB

EFTUD2

Tbio

Novelty:  0.01805571

Score:  0.996

Data Source:  STRINGDB

PRPF31

Tbio

Novelty:  0.0105753

Score:  0.996

Data Source:  STRINGDB

LSM8

Tbio

Novelty:  0.08782322

Score:  0.995

Data Source:  STRINGDB

SNRNP40

Tbio

Novelty:  0.16791896

Score:  0.995

Data Source:  STRINGDB

SNRPG

Tbio

Novelty:  0.1684808

Score:  0.994

Data Source:  STRINGDB

PRPF6

Tbio

Novelty:  0.02818008

Score:  0.994

Data Source:  STRINGDB

SNRPD2

Tbio

Novelty:  0.02519503

Score:  0.994

Data Source:  STRINGDB

SNRPD1

Tbio

Novelty:  0.0136355

Score:  0.994

Data Source:  STRINGDB

Pathways (5)

Reactome (4)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Gene Ontology Terms (13)

Functions (2)

Components (4)

Processes (7)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
thiol-dependent ubiquitinyl hydrolase activity	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

GWAS Traits (19)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	7	6	4	1.1	94.9
prostate carcinoma	EFO_0001663	6	4	1	1.1	90
serum gamma-glutamyl transferase measurement	EFO_0004532	2	3	3		81.1
myocardial infarction	EFO_0000612	3	2	0	1.1	69.6
eosinophil count	EFO_0004842	3	1	3		62.8

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	4	1.1	94.9
prostate carcinoma	EFO_0001663	1	1.1	90
serum gamma-glutamyl transferase measurement	EFO_0004532	3		81.1
myocardial infarction	EFO_0000612	0	1.1	69.6
eosinophil count	EFO_0004842	3		62.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Isopeptide bond
Metal-binding
mRNA processing
mRNA splicing
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
albuminuria
basophil count
breast carcinoma
cancer
coronary artery disease
eosinophil count
eosinophil percentage of leukocytes
myocardial infarction
ovarian carcinoma
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
integument phenotype
pigmentation phenotype

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ubiquitin specific peptidase 39	VGNC:10805	459369
Macaque	ubiquitin specific peptidase 39		696217
Mouse	ubiquitin specific peptidase 39	MGI:107622	28035
Rat	ubiquitin specific peptidase 39	RGD:1308103	297336
Dog	ubiquitin specific peptidase 39	VGNC:48194	475767

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ubiquitin specific peptidase 39
Macaque	ubiquitin specific peptidase 39
Mouse	ubiquitin specific peptidase 39
Rat	ubiquitin specific peptidase 39
Dog	ubiquitin specific peptidase 39

Publication Statistics

PubMed Score 40.03

PubMed score by year

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PubTator Score 30.15

PubTator score by year

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