USP39
U4/U6.U5 tri-snRNP-associated protein 2
Protein Summary
Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397).
- ENST00000323701
- ENSP00000312981
- ENSG00000168883
- ENST00000409470
- ENSP00000386864
- ENST00000409766
- ENSP00000386803
- ENST00000450066
- ENSP00000396133
- 65K
- SAD1
- CGI-21
- HSPC332
- SNRNP65
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 1 | ||
disease perturbation | 0.9 | ||
transcription factor perturbation | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.03 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 140 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.03 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 140 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (257)
PRPF4
Novelty: 0.08229072
p_int: 0.961594902
p_ni: 0.038405098
Score: 0.983
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | mRNA Splicing | ||||
Reactome | mRNA Splicing - Major Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
mRNA Splicing | ||||
mRNA Splicing - Major Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 6 | 4 | 1.1 | 94.9 | |||||
6 | 4 | 1 | 1.1 | 90 | |||||
serum gamma-glutamyl transferase measurement | 2 | 3 | 3 | 81.1 | |||||
3 | 2 | 0 | 1.1 | 69.6 | |||||
eosinophil count | 3 | 1 | 3 | 62.8 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
4 | 1.1 | 94.9 | |||||
1 | 1.1 | 90 | |||||
serum gamma-glutamyl transferase measurement | 3 | 81.1 | |||||
0 | 1.1 | 69.6 | |||||
eosinophil count | 3 | 62.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin specific peptidase 39 | VGNC:10805 | 459369 | |||||
Macaque | ubiquitin specific peptidase 39 | 696217 | ||||||
Mouse | MGI:107622 | 28035 | ||||||
Rat | RGD:1308103 | 297336 | ||||||
Dog | ubiquitin specific peptidase 39 | VGNC:48194 | 475767 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquitin specific peptidase 39 | |||||
Macaque | ubiquitin specific peptidase 39 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquitin specific peptidase 39 | |||||
Publication Statistics
PubMed Score 40.03
PubMed score by year
PubTator Score 30.15
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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