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Tbio
USP39
U4/U6.U5 tri-snRNP-associated protein 2

Protein Summary
Description
Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323701
  • ENSP00000312981
  • ENSG00000168883
  • ENST00000409470
  • ENSP00000386864
  • ENST00000409766
  • ENSP00000386803
  • ENST00000450066
  • ENSP00000396133

Symbol
  • 65K
  • SAD1
  • CGI-21
  • HSPC332
  • SNRNP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.9
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.03   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.03   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (257)
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.961594902
p_ni:  0.038405098
Score:  0.983
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.998
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.996
Data Source:  STRINGDB
PRPF31
Tbio
Novelty:  0.0105753
Score:  0.996
Data Source:  STRINGDB
LSM8
Tbio
Novelty:  0.08782322
Score:  0.995
Data Source:  STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
Score:  0.995
Data Source:  STRINGDB
SNRPG
Tbio
Novelty:  0.1684808
Score:  0.994
Data Source:  STRINGDB
PRPF6
Tbio
Novelty:  0.02818008
Score:  0.994
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.994
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
6
4
1.1
94.9
6
4
1
1.1
90
serum gamma-glutamyl transferase measurement
2
3
3
81.1
3
2
0
1.1
69.6
eosinophil count
3
1
3
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
94.9
1
1.1
90
serum gamma-glutamyl transferase measurement
3
81.1
0
1.1
69.6
eosinophil count
3
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 39
VGNC:10805
459369
Macaque
ubiquitin specific peptidase 39
696217
Mouse
MGI:107622
28035
Rat
RGD:1308103
297336
Dog
ubiquitin specific peptidase 39
VGNC:48194
475767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 39
Macaque
ubiquitin specific peptidase 39
Mouse
Rat
Dog
ubiquitin specific peptidase 39
Publication Statistics
PubMed Score 40.03
PubMed score by year
PubTator Score 30.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title