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Tbio
GLE1
Nucleoporin GLE1

Protein Summary
Description
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309971
  • ENSP00000308622
  • ENSG00000119392
  • ENST00000372770
  • ENSP00000361856

Symbol
  • GLE1L
  • LCCS
  • CAAHC
  • CAAHD
  • GLE1L
  • LCCS1
  • hGLE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor perturbation
0.84
histone modification site profile
0.83
kinase perturbation
0.76
tissue
0.66


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.54   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.54   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLE1, RNA export mediator
VGNC:4753
464770
Macaque
GLE1, RNA export mediator
717474
Mouse
MGI:1921662
74412
Rat
RGD:1307329
362098
Dog
GLE1, RNA export mediator
VGNC:41254
480704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLE1, RNA export mediator
Macaque
GLE1, RNA export mediator
Mouse
Rat
Dog
GLE1, RNA export mediator
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q53GS7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Transport of Mature Transcript to Cytoplasm
Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Transport of Mature Transcript to Cytoplasm
Transport of Mature mRNA derived from an Intron-Containing Transcript
Protein-Protein Interactions (171)
1 – 10 of 171
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.999998905
p_ni: 0.000001095
Score: 0.444
Data Source: BioPlex,STRINGDB
NXF1
Tbio
Novelty: 0.00642439
p_int: 0.999655483
p_ni: 0.000344516
Score: 0.989
Data Source: BioPlex,STRINGDB
IER2
Tbio
Novelty: 0.03864806
p_int: 0.994288297
p_ni: 0.005711649
p_wrong: 5.3e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty: 0.01125284
p_int: 0.978190836
p_ni: 0.021809164
Data Source: BioPlex
CARNMT1
Tbio
Family: Enzyme
Novelty: 0.28121779
p_int: 0.953076536
p_ni: 0.046923464
Score: 0.182
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.948578916
p_ni: 0.051419856
p_wrong: 0.000001229
Data Source: BioPlex
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.926276938
p_ni: 0.073723062
Score: 0.264
Data Source: BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.925516317
p_ni: 0.074483102
p_wrong: 5.81e-7
Data Source: BioPlex
HEATR3
Tbio
Novelty: 0.08367436
p_int: 0.899192627
p_ni: 0.100787227
p_wrong: 0.000020146
Data Source: BioPlex
NUP214
Tbio
Novelty: 0.00924336
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.54

PubMed score by year
PubTator Score  55.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer