You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PARP10
Poly [ADP-ribose] polymerase 10

Protein Summary
Description
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313028
  • ENSP00000325618
  • ENSG00000178685

Symbol
  • ARTD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.78
tissue sample
0.77
cell type or tissue
0.67
cell line
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.98   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.98   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
rucaparib
Rendered image for rucaparib
Active Ligands (17)
1 – 10 of 17
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
8
11
96.6
platelet count
3
2
2
2.3
94.5
mean corpuscular volume
2
2
2
90.4
blood metabolite measurement
1
2
2
89.7
total cholesterol measurement
4
4
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
11
96.6
platelet count
2
2.3
94.5
mean corpuscular volume
2
90.4
blood metabolite measurement
2
89.7
total cholesterol measurement
4
89.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
poly(ADP-ribose) polymerase family member 10
708132
Mouse
MGI:3712326
671535
Rat
RGD:7744876
102548778
Horse
poly(ADP-ribose) polymerase family member 10
106781003
Cow
poly(ADP-ribose) polymerase family member 10
510991
Species
Name
OMA
EggNOG
Inparanoid
Macaque
poly(ADP-ribose) polymerase family member 10
Mouse
Rat
Horse
poly(ADP-ribose) polymerase family member 10
Cow
poly(ADP-ribose) polymerase family member 10
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q53GL7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Protein-Protein Interactions (51)
1 – 10 of 51
OARD1
Tdark
Family:  Enzyme
Novelty:  0.14445866
Score:  0.773
Data Source:  STRINGDB
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
Score:  0.718
Data Source:  STRINGDB
PARP3
Tclin
Family:  Enzyme
Novelty:  0.01712237
Score:  0.713
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.707
Data Source:  STRINGDB
PARP8
Tdark
Family:  Enzyme
Novelty:  0.29808738
Score:  0.7
Data Source:  STRINGDB
PARP6
Tchem
Family:  Enzyme
Novelty:  0.10074447
Score:  0.7
Data Source:  STRINGDB
PLEC
Tbio
Novelty:  0.00223244
Score:  0.686
Data Source:  STRINGDB
PARP4
Tchem
Family:  Enzyme
Novelty:  0.02135745
Score:  0.683
Data Source:  STRINGDB
MACROD1
Tchem
Family:  Enzyme
Novelty:  0.03610474
Score:  0.678
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.673
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.98

PubMed score by year
PubTator Score  19.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: