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Tdark
ZNF394
Zinc finger protein 394

Protein Summary
Description
May be involved in transcriptional regulation. The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337673
  • ENSP00000337363
  • ENSG00000160908
  • ENST00000426306
  • ENSP00000409565

Symbol
  • ZKSCAN14
  • ZSCAN46
  • ZKSCAN14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.78
cell type or tissue
0.69
transcription factor perturbation
0.68
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
1
2
75.1
smoking behaviour measurement
1
1
1
65.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
2
75.1
smoking behaviour measurement
1
65.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 394
VGNC:4575
463573
Macaque
zinc finger protein 394
718740
Mouse
MGI:1914485
67235
Rat
RGD:628654
252860
Dog
zinc finger protein 394
VGNC:54096
479741
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 394
Macaque
zinc finger protein 394
Mouse
Rat
Dog
zinc finger protein 394
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (13)
1 – 10 of 13
ZSCAN32
Tdark
Family: TF
Novelty: 3.83392226
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.812
Data Source: BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty: 0.0189038
p_int: 0.999995697
p_ni: 0.000004303
Score: 0.187
Data Source: BioPlex,STRINGDB
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.999994395
p_ni: 0.000005598
p_wrong: 8e-9
Score: 0.764
Data Source: BioPlex,STRINGDB
ZNF397
Tbio
Family: TF
Novelty: 0.60034816
p_int: 0.997503149
p_ni: 0.000232447
p_wrong: 0.002264404
Score: 0.818
Data Source: BioPlex,STRINGDB
SCAND1
Tbio
Novelty: 0.06863895
p_int: 0.816114515
p_ni: 0.031096933
p_wrong: 0.152788552
Score: 0.822
Data Source: BioPlex,STRINGDB
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.903
Data Source: STRINGDB
C1orf53
Tdark
Novelty: 5.84662738
Score: 0.538
Data Source: STRINGDB
BTBD11
Tdark
Novelty: 0.73957895
Score: 0.498
Data Source: STRINGDB
SCML1
Tdark
Novelty: 0.60106322
Score: 0.475
Data Source: STRINGDB
ASB2
Tbio
Novelty: 0.02852942
Score: 0.412
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.86

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer