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Tbio
SLC44A4
Choline transporter-like protein 4

Protein Summary
Description
Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411). Isoform 3: Has also thiamine pyrophosphate transporter activity. The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229729
  • ENSP00000229729
  • ENSG00000204385
  • ENST00000375562
  • ENSP00000364712
  • ENST00000383379
  • ENSP00000372870
  • ENSG00000206378
  • ENST00000415517
  • ENSP00000414120
  • ENSG00000229077
  • ENST00000417894
  • ENSP00000389244
  • ENSG00000235336
  • ENST00000425238
  • ENSP00000399161
  • ENSG00000228263
  • ENST00000442152
  • ENSP00000398852
  • ENSG00000232180
  • ENST00000453831
  • ENSP00000393939
  • ENSG00000231479
  • ENST00000544672
  • ENSP00000444109
  • ENST00000546461
  • ENSP00000449039
  • ENST00000547493
  • ENSP00000449232
  • ENST00000547684
  • ENSP00000449180
  • ENST00000548188
  • ENSP00000447560
  • ENST00000549663
  • ENSP00000449642
  • ENST00000549677
  • ENSP00000449518
  • ENST00000550401
  • ENSP00000448474
  • ENST00000551168
  • ENSP00000448088
  • ENST00000553121
  • ENSP00000447704
  • ENST00000644409
  • ENSP00000496109

Symbol
  • C6orf29
  • CTL4
  • NG22
  • TPPT1
  • CTL4
  • NG22
  • TPPT
  • DFNA72
  • hTPPT1
  • C6orf29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
phenotype
0.73
disease
0.65
biological process
0.62
cell line
0.6


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.46   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.46   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (432)
Items per page:
1 – 5 of 432
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
8
0
1.9
99.2
9
8
0
1.9
99.2
9
8
0
1.9
99.2
9
8
0
1.9
99.2
9
8
0
1.9
99.2
Items per page:
1 – 5 of 432
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
99.2
0
1.9
99.2
0
1.9
99.2
0
1.9
99.2
0
1.9
99.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 44 member 4
715779
Mouse
MGI:1917379
70129
Rat
RGD:1303167
294255
Dog
solute carrier family 44 member 4
VGNC:46420
481718
Horse
solute carrier family 44 member 4
VGNC:23221
100051054
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 44 member 4
Mouse
Rat
Dog
solute carrier family 44 member 4
Horse
solute carrier family 44 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q53GD3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
SLC-mediated transmembrane transport
Protein-Protein Interactions (21)
1 – 10 of 21
SLC5A7
Tchem
Family:  Transporter
Novelty:  0.00232251
Score:  0.733
Data Source:  STRINGDB
EPS8L3
Tbio
Family:  Enzyme
Novelty:  0.15726999
Score:  0.585
Data Source:  STRINGDB
SLC25A32
Tbio
Family:  Transporter
Novelty:  0.06270404
Score:  0.528
Data Source:  STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.51
Data Source:  STRINGDB
RNF144A
Tbio
Family:  Enzyme
Novelty:  0.13172374
Score:  0.509
Data Source:  STRINGDB
SLC2A13
Tbio
Family:  Transporter
Novelty:  0.04641021
Score:  0.505
Data Source:  STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
Score:  0.497
Data Source:  STRINGDB
SLC18A3
Tchem
Family:  Transporter
Novelty:  0.00169007
Score:  0.487
Data Source:  STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.452
Data Source:  STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
Score:  0.44
Data Source:  STRINGDB
Publication Statistics
PubMed Score  42.46

PubMed score by year
PubTator Score  26.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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