PHLDA2
Pleckstrin homology-like domain family A member 2
Protein Summary
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
- ENST00000314222
- ENSP00000319231
- ENSG00000181649
- ENST00000618418
- ENSP00000483602
- ENSG00000274538
- ENST00000645523
- ENSP00000495265
- BWR1C
- HLDA2
- IPL
- TSSC3
- IPL
- BRW1C
- BWR1C
- HLDA2
- TSSC3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.97 | ||
histone modification site profile | 0.85 | ||
transcription factor binding site profile | 0.84 | ||
gene perturbation | 0.8 | ||
small molecule perturbation | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 282 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 282 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0