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Tbio
KLHL12
Kelch-like protein 12

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367261
  • ENSP00000356230
  • ENSG00000117153

Symbol
  • C3IP1
  • DKIR
  • C3IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.92
histone modification site profile
0.84
transcription factor binding site profile
0.84
interacting protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.948855779
p_ni:  0.051144221
Data Source:  BioPlex
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.940849318
p_ni:  0.059150682
Score:  0.71
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.991
Data Source:  Reactome,STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.976
Data Source:  Reactome,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.975
Data Source:  STRINGDB
PEF1
Tbio
Novelty:  0.01442356
Score:  0.965
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.965
Data Source:  Reactome,STRINGDB
SEC31A
Tbio
Novelty:  0.0350228
Score:  0.963
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.961
Data Source:  STRINGDB
SEC31B
Tdark
Novelty:  0.35742768
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Degradation of DVL (R-HSA-4641258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of DVL
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Degradation of DVL
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
75.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 12
VGNC:6898
457634
Macaque
kelch like family member 12
705991
Mouse
MGI:2385619
240756
Rat
RGD:628717
266772
Dog
kelch like family member 12
VGNC:42448
479996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 12
Macaque
kelch like family member 12
Mouse
Rat
Dog
kelch like family member 12
Publication Statistics
PubMed Score 18.65
PubMed score by year
PubTator Score 7.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title