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Tbio
HIKESHI
Protein Hikeshi

Protein Summary
Description
Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278483
  • ENSP00000278483
  • ENSG00000149196

Symbol
  • C11orf73
  • HLD13
  • L7RN6
  • OPI10
  • HSPC138
  • HSPC179
  • C11orf73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.997830261
p_ni:  0.001939191
p_wrong:  0.000230548
Data Source:  BioPlex
ZNF581
Tdark
Family:  TF
Novelty:  18
p_int:  0.990145349
p_ni:  0.009854648
p_wrong:  3e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  0.97580988
p_ni:  0.02419011
p_wrong:  1e-8
Score:  0.401
Data Source:  BioPlex,STRINGDB
RCVRN
Tbio
Novelty:  0.00266222
p_int:  0.973844022
p_ni:  0.026155969
p_wrong:  9e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.913429228
p_ni:  0.086570772
Score:  0.173
Data Source:  BioPlex,STRINGDB
SIRPD
Tdark
Novelty:  4.75114214
p_int:  0.90703592
p_ni:  0.090362362
p_wrong:  0.002601718
Score:  0.332
Data Source:  BioPlex,STRINGDB
PHB
Tbio
Novelty:  0.00178383
p_int:  0.874658542
p_ni:  0.125336637
p_wrong:  0.000004821
Score:  0.301
Data Source:  BioPlex,STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.964
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.959
Data Source:  STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.955
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
63.1
smoking initiation
2
2
2
39.6
smoking behavior
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
63.1
smoking initiation
2
39.6
smoking behavior
1
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Hikeshi, heat shock protein nuclear import factor
VGNC:3186
749099
Macaque
Hikeshi, heat shock protein nuclear import factor
704098
Mouse
MGI:96738
67669
Rat
RGD:1359455
293103
Dog
Hikeshi, heat shock protein nuclear import factor
VGNC:41689
476778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Hikeshi, heat shock protein nuclear import factor
Macaque
Hikeshi, heat shock protein nuclear import factor
Mouse
Rat
Dog
Hikeshi, heat shock protein nuclear import factor
Publication Statistics
PubMed Score 17.65
PubMed score by year
PubTator Score 10.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title