Tbio HIKESHI Protein Hikeshi

Protein Summary

Description

Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q53FT3
• Q8WVE8
• Q9NVQ2
• Q9NZZ1
• Q9P022
• Q9P0N1

Gene Name

• HIKESHI

Ensembl ID

• ENST00000278483
• ENSP00000278483
• ENSG00000149196

Symbol

• C11orf73
• HLD13
• L7RN6
• OPI10
• HSPC138
• HSPC179
• C11orf73

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

CLEC3A

Tdark

Novelty:  0.21498836

p_int:  0.997830261

p_ni:  0.001939191

p_wrong:  0.000230548

Data Source:  BioPlex

ZNF581

Tdark

Family:  TF

Novelty:  18

p_int:  0.990145349

p_ni:  0.009854648

p_wrong:  3e-9

Score:  0.23

Data Source:  BioPlex,STRINGDB

COMMD10

Tbio

Novelty:  0.29057641

p_int:  0.97580988

p_ni:  0.02419011

p_wrong:  1e-8

Score:  0.401

Data Source:  BioPlex,STRINGDB

RCVRN

Tbio

Novelty:  0.00266222

p_int:  0.973844022

p_ni:  0.026155969

p_wrong:  9e-9

Score:  0.332

Data Source:  BioPlex,STRINGDB

TRMT61B

Tbio

Family:  Enzyme

Novelty:  0.32929047

p_int:  0.913429228

p_ni:  0.086570772

Score:  0.173

Data Source:  BioPlex,STRINGDB

SIRPD

Tdark

Novelty:  4.75114214

p_int:  0.90703592

p_ni:  0.090362362

p_wrong:  0.002601718

Score:  0.332

Data Source:  BioPlex,STRINGDB

PHB

Tbio

Novelty:  0.00178383

p_int:  0.874658542

p_ni:  0.125336637

p_wrong:  0.000004821

Score:  0.301

Data Source:  BioPlex,STRINGDB

HSPA4

Tbio

Novelty:  0.00009122

Score:  0.964

Data Source:  STRINGDB

HSPA8

Tchem

Novelty:  0.00081014

Score:  0.959

Data Source:  STRINGDB

DNAJB1

Tbio

Novelty:  0.00139956

Score:  0.955

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Cellular response to heat stress (R-HSA-3371556)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Regulation of HSF1-mediated heat shock response	82 targets	R-HSA-3371453

Name	Explore in Pharos	Explore in Source
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Regulation of HSF1-mediated heat shock response	82 targets	R-HSA-3371453

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (4)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
Hsp70 protein binding	Inferred from Direct Assay (IDA)	UniProtKB
protein transporter activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	2	1	2		63.1
smoking initiation	EFO_0005670	2	2	2		39.6
smoking behavior	EFO_0004318	1	1	1		4.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	2		63.1
smoking initiation	EFO_0005670	2		39.6
smoking behavior	EFO_0004318	1		4.6

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UniProt Keyword Find Similar Targets

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3D-structure
Complete proteome
Cytoplasm
Disease mutation
Leukodystrophy
Nucleus
Polymorphism
Protein transport
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
smoking behavior
smoking initiation
smoking status measurement

MGI Phenotype Find Similar Targets

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homeostasis/metabolism phenotype
mortality/aging
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Hikeshi, heat shock protein nuclear import factor	VGNC:3186	749099
Macaque	Hikeshi, heat shock protein nuclear import factor		704098
Mouse	heat shock protein nuclear import factor	MGI:96738	67669
Rat	Hikeshi, heat shock protein nuclear import factor	RGD:1359455	293103
Dog	Hikeshi, heat shock protein nuclear import factor	VGNC:41689	476778

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Hikeshi, heat shock protein nuclear import factor
Macaque	Hikeshi, heat shock protein nuclear import factor
Mouse	heat shock protein nuclear import factor
Rat	Hikeshi, heat shock protein nuclear import factor
Dog	Hikeshi, heat shock protein nuclear import factor

Publication Statistics

PubMed Score 17.65

PubMed score by year

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PubTator Score 10.10

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Related Publications

Text Mined References (17)

GeneRif Annotations (6)

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PMID	Year	Title