Protein Summary
Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition ...more
- ENST00000278483
- ENSP00000278483
- ENSG00000149196
- C11orf73
- HLD13
- L7RN6
- OPI10
- HSPC138
- HSPC179
- C11orf73
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.65 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.65 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
CLEC3A
Novelty: 0.21498836
p_int: 0.997830261
p_ni: 0.001939191
p_wrong: 0.000230548
Data Source: BioPlex
ZNF581
Family: TF
Novelty: 18
p_int: 0.990145349
p_ni: 0.009854648
p_wrong: 3e-9
Score: 0.23
Data Source: BioPlex,STRINGDB
COMMD10
Novelty: 0.29057641
p_int: 0.97580988
p_ni: 0.02419011
p_wrong: 1e-8
Score: 0.401
Data Source: BioPlex,STRINGDB
RCVRN
Novelty: 0.00266222
p_int: 0.973844022
p_ni: 0.026155969
p_wrong: 9e-9
Score: 0.332
Data Source: BioPlex,STRINGDB
TRMT61B
Family: Enzyme
Novelty: 0.32929047
p_int: 0.913429228
p_ni: 0.086570772
Score: 0.173
Data Source: BioPlex,STRINGDB
SIRPD
Novelty: 4.75114214
p_int: 0.90703592
p_ni: 0.090362362
p_wrong: 0.002601718
Score: 0.332
Data Source: BioPlex,STRINGDB
PHB
Novelty: 0.00178383
p_int: 0.874658542
p_ni: 0.125336637
p_wrong: 0.000004821
Score: 0.301
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Regulation of HSF1-mediated heat shock response | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Regulation of HSF1-mediated heat shock response | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 1 | 2 | 63.1 | |||||
smoking initiation | 2 | 2 | 2 | 39.6 | |||||
smoking behavior | 1 | 1 | 1 | 4.6 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 63.1 | |||||
smoking initiation | 2 | 39.6 | |||||
smoking behavior | 1 | 4.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | Hikeshi, heat shock protein nuclear import factor | VGNC:3186 | 749099 | |||||
Macaque | Hikeshi, heat shock protein nuclear import factor | 704098 | ||||||
Mouse | MGI:96738 | 67669 | ||||||
Rat | RGD:1359455 | 293103 | ||||||
Dog | Hikeshi, heat shock protein nuclear import factor | VGNC:41689 | 476778 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | Hikeshi, heat shock protein nuclear import factor | |||||
Macaque | Hikeshi, heat shock protein nuclear import factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | Hikeshi, heat shock protein nuclear import factor | |||||
Publication Statistics
PubMed Score 17.65
PubMed score by year
PubTator Score 10.10
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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