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Tbio
TP53I3
Quinone oxidoreductase PIG3

Protein Summary
Description
May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238721
  • ENSP00000238721
  • ENSG00000115129
  • ENST00000335934
  • ENSP00000337834
  • ENST00000407482
  • ENSP00000384414

Symbol
  • PIG3
  • PIG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
cell type or tissue
0.73
kinase perturbation
0.71
PubMedID
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.5   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.5   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53 inducible protein 3
VGNC:10793
459062
Macaque
tumor protein p53 inducible protein 3
704206
Dog
tumor protein p53 inducible protein 3
VGNC:47724
610825
Horse
tumor protein p53 inducible protein 3
VGNC:24422
100071618
Cow
tumor protein p53 inducible protein 3
VGNC:36235
508875
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53 inducible protein 3
Macaque
tumor protein p53 inducible protein 3
Dog
tumor protein p53 inducible protein 3
Horse
tumor protein p53 inducible protein 3
Cow
tumor protein p53 inducible protein 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q53FA7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Protein-Protein Interactions (29)
1 – 10 of 29
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.963
Data Source: STRINGDB
TP53BP2
Tbio
Novelty: 0.01058379
Score: 0.948
Data Source: STRINGDB
TP73
Tbio
Family: TF
Novelty: 0.00667737
Score: 0.92
Data Source: STRINGDB
TP63
Tbio
Family: TF
Novelty: 0.00336108
Score: 0.915
Data Source: STRINGDB
PPP1R13B
Tbio
Novelty: 0.03903985
Score: 0.914
Data Source: STRINGDB
EI24
Tbio
Novelty: 0.02042684
Score: 0.893
Data Source: STRINGDB
SESN1
Tbio
Novelty: 0.0125888
Score: 0.625
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.00789975
Score: 0.623
Data Source: STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
Score: 0.604
Data Source: STRINGDB
BBC3
Tbio
Novelty: 0.00773944
Score: 0.53
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.50

PubMed score by year
PubTator Score  37.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer