Tbio CEP55 Centrosomal protein of 55 kDa

Protein Summary

Description

Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).

Uniprot Accession IDs

• Q53EZ4
• B2RDG8
• D3DR37
• Q32WF5
• Q3MV20
• Q5VY28
• Q6N034
• Q96H32
• Q9NVS7
• Cep55

Gene Name

• CEP55

Ensembl ID

• ENST00000371485
• ENSP00000360540
• ENSG00000138180

Symbol

• C10orf3
• URCC6
• CT111
• MARCH
• URCC6
• C10orf3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.89
drug perturbation	0.87
histone modification site profile	0.83
interacting protein	0.77
transcription factor binding site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.85   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.85   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0