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Tbio
CRTC2
CREB-regulated transcription coactivator 2

Protein Summary
Description
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368633
  • ENSP00000357622
  • ENSG00000160741

Symbol
  • TORC2
  • TORC2
  • TORC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
kinase
0.84
transcription factor binding site profile
0.8
biological term
0.7
transcription factor
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.27   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.27   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first birth measurement
1
1
1
32.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first birth measurement
1
32.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CREB regulated transcription coactivator 2
VGNC:10591
738694
Macaque
CREB regulated transcription coactivator 2
715908
Mouse
MGI:1921593
74343
Rat
RGD:1308903
310615
Dog
CREB regulated transcription coactivator 2
VGNC:53339
612305
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CREB regulated transcription coactivator 2
Macaque
CREB regulated transcription coactivator 2
Mouse
Rat
Dog
CREB regulated transcription coactivator 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q53ET0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Circadian Clock
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (84)
1 – 10 of 84
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.988727982
p_ni: 0.000002159
p_wrong: 0.011269858
Data Source: BioPlex
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.988717653
p_ni: 0.011282346
p_wrong: 1e-9
Score: 0.955
Data Source: BioPlex,STRINGDB
PPP3R1
Tbio
Novelty: 0.00263264
p_int: 0.945825137
p_ni: 0.054174863
Score: 0.902
Data Source: BioPlex,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
p_int: 0.919147043
p_ni: 0.080852957
Score: 0.914
Data Source: BioPlex,STRINGDB
YWHAG
Tbio
Novelty: 0.00845572
p_int: 0.86491948
p_ni: 0.13508052
Score: 0.914
Data Source: BioPlex,STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
p_int: 0.796732635
p_ni: 0.203267365
Score: 0.917
Data Source: BioPlex,STRINGDB
PPP3CB
Tbio
Family: Enzyme
Novelty: 0.02156713
p_int: 0.766784963
p_ni: 0.233215037
Score: 0.944
Data Source: BioPlex,STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.999
Data Source: Reactome,STRINGDB
SIK2
Tchem
Family: Kinase
Novelty: 0.01957886
Score: 0.987
Data Source: STRINGDB
SIK1
Tchem
Family: Kinase
Novelty: 0.00523549
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.27

PubMed score by year
PubTator Score  91.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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