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Tdark
FAM98B
Protein FAM98B

Protein Summary
Description
Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397609
  • ENSP00000380734
  • ENSG00000171262
  • ENST00000491535
  • ENSP00000453166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
transcription factor perturbation
0.84
transcription factor binding site profile
0.77
tissue sample
0.63
histone modification site profile
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
71.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 98 member B
VGNC:11887
453315
Macaque
family with sequence similarity 98 member B
106999137
Mouse
MGI:1915465
68215
Rat
Dog
family with sequence similarity 98 member B
VGNC:40713
478254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 98 member B
Macaque
family with sequence similarity 98 member B
Mouse
Rat
Dog
family with sequence similarity 98 member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q52LJ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
DDX1
Tbio
Family: Enzyme
Novelty: 0.01691884
p_int: 0.999643472
p_ni: 0.000356528
Score: 0.999
Data Source: BioPlex,STRINGDB
RTRAF
Tbio
Novelty: 0.03996206
Score: 0.999
Data Source: STRINGDB
C2orf49
Tbio
Novelty: 0.03911934
Score: 0.998
Data Source: STRINGDB
RTCB
Tbio
Family: Enzyme
Novelty: 0.01114311
Score: 0.998
Data Source: STRINGDB
ZBTB8OS
Tbio
Family: Enzyme
Novelty: 0.03929334
Score: 0.971
Data Source: STRINGDB
RNPEP
Tchem
Family: Enzyme
Novelty: 0.00381273
Score: 0.873
Data Source: STRINGDB
PAFAH1B2
Tchem
Family: Enzyme
Novelty: 0.07918203
Score: 0.859
Data Source: STRINGDB
PPP1R8
Tbio
Family: Enzyme
Novelty: 0.00138054
Score: 0.833
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.68
Data Source: STRINGDB
MORC3
Tbio
Novelty: 0.01216555
Score: 0.674
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.17

PubMed score by year
PubTator Score  0.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer