Tdark FAM98B Protein FAM98B

Protein Summary

Description

Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).

Uniprot Accession IDs

• Q52LJ0
• A8MUW5
• Q8N935

Gene Name

• FAM98B

Ensembl ID

• ENST00000397609
• ENSP00000380734
• ENSG00000171262
• ENST00000491535
• ENSP00000453166

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
transcription factor perturbation	0.84
transcription factor binding site profile	0.77
tissue sample	0.63
histone modification site profile	0.56

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic lupus erythematosus	EFO_0002690	1	1	0	1.9	71.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic lupus erythematosus	EFO_0002690	0	1.9	71.1

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	family with sequence similarity 98 member B	VGNC:11887	453315
Macaque	family with sequence similarity 98 member B		106999137
Mouse	family with sequence similarity 98, member B	MGI:1915465	68215
Rat	-
Dog	family with sequence similarity 98 member B	VGNC:40713	478254

Species	Name	OMA	EggNOG	Inparanoid
Chimp	family with sequence similarity 98 member B
Macaque	family with sequence similarity 98 member B
Mouse	family with sequence similarity 98, member B
Rat	-
Dog	family with sequence similarity 98 member B

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q52LJ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)

Reactome (3)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	tRNA processing	123 targets	R-HSA-72306
Reactome	tRNA processing in the nucleus	58 targets	R-HSA-6784531

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
tRNA processing	123 targets	R-HSA-72306
tRNA processing in the nucleus	58 targets	R-HSA-6784531

Gene Ontology Terms (11)

Functions (3)

Components (5)

Processes (3)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Direct Assay (IDA)	UniProtKB
protein methyltransferase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

DDX1

Tbio

Family: Enzyme

Novelty: 0.01691884

p_int: 0.999643472

p_ni: 0.000356528

Score: 0.999

Data Source: BioPlex,STRINGDB

RTRAF

Tbio

Novelty: 0.03996206

Score: 0.999

Data Source: STRINGDB

C2orf49

Tbio

Novelty: 0.03911934

Score: 0.998

Data Source: STRINGDB

RTCB

Tbio

Family: Enzyme

Novelty: 0.01114311

Score: 0.998

Data Source: STRINGDB

ZBTB8OS

Tbio

Family: Enzyme

Novelty: 0.03929334

Score: 0.971

Data Source: STRINGDB

RNPEP

Tchem

Family: Enzyme

Novelty: 0.00381273

Score: 0.873

Data Source: STRINGDB

PAFAH1B2

Tchem

Family: Enzyme

Novelty: 0.07918203

Score: 0.859

Data Source: STRINGDB

PPP1R8

Tbio

Family: Enzyme

Novelty: 0.00138054

Score: 0.833

Data Source: STRINGDB

TP53BP1

Tbio

Family: Epigenetic

Novelty: 0.00131256

Score: 0.68

Data Source: STRINGDB

MORC3

Tbio

Novelty: 0.01216555

Score: 0.674

Data Source: STRINGDB

Publication Statistics

PubMed Score  1.17

PubMed score by year

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PubTator Score  0.62

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
Cytoplasm
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

systemic lupus erythematosus