Tdark KRTAP13-2 Keratin-associated protein 13-2

Protein Summary

Description

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Uniprot Accession IDs

• Q52LG2

Gene Name

• KRTAP13-2

Ensembl ID

• ENST00000399889
• ENSP00000382777
• ENSG00000182816

Symbol

• KAP13.2
• KAP13-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.44
cell type or tissue	0.37
cell line	0.36
disease perturbation	0.36
gene perturbation	0.36

Protein Classes

PANTHER Classes

Protein / Structural Protein / Keratin-associated Protein 13-2

DTO Classes

Protein / Cellular Structure / Keratin-associated Protein 13-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0