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Tbio
LIN52
Protein lin-52 homolog

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000555028
  • ENSP00000451812
  • ENSG00000205659

Symbol
  • C14orf46
  • C14orf46
  • c14_5549
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.79
transcription factor binding site profile
0.72
tissue sample
0.69
ligand (protein) perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
6
98.5
ganglion cell inner plexiform layer thickness measurement
1
1
1
59
self reported educational attainment
1
1
1
40.7
mean corpuscular volume
1
1
1
39.6
mean reticulocyte volume
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
98.5
ganglion cell inner plexiform layer thickness measurement
1
59
self reported educational attainment
1
40.7
mean corpuscular volume
1
39.6
mean reticulocyte volume
1
26.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-52 DREAM MuvB core complex component
VGNC:7640
453030
Mouse
MGI:3045391
217708
Rat
RGD:1306798
362763
Dog
lin-52 DREAM MuvB core complex component
VGNC:50543
611889
Horse
lin-52 DREAM MuvB core complex component
VGNC:19676
100050909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-52 DREAM MuvB core complex component
Mouse
Rat
Dog
lin-52 DREAM MuvB core complex component
Horse
lin-52 DREAM MuvB core complex component
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q52LA3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
G0 and Early G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
G0 and Early G1
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
LIN37
Tdark
Novelty:  0.27040489
p_int:  0.999999983
p_ni:  1.1e-8
p_wrong:  6e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYBL1
Tbio
Family:  TF
Novelty:  0.00695014
p_int:  0.999995648
p_ni:  6.79e-7
p_wrong:  0.000003674
Score:  0.951
Data Source:  BioPlex,STRINGDB
LIN9
Tbio
Novelty:  0.01112853
p_int:  0.99998444
p_ni:  1.89e-7
p_wrong:  0.000015371
Score:  0.999
Data Source:  BioPlex,STRINGDB
RBL1
Tbio
Novelty:  0.00228265
Score:  0.995
Data Source:  STRINGDB
LIN54
Tbio
Novelty:  0.06173892
Score:  0.995
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.985
Data Source:  STRINGDB
MYBL2
Tbio
Family:  TF
Novelty:  0.00405647
Score:  0.978
Data Source:  STRINGDB
RBL2
Tbio
Novelty:  0.00121893
Score:  0.974
Data Source:  STRINGDB
DYRK1A
Tchem
Family:  Kinase
Novelty:  0.00226963
Score:  0.974
Data Source:  STRINGDB
E2F4
Tbio
Family:  TF
Novelty:  0.00317412
Score:  0.974
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.17

PubMed score by year
PubTator Score  2.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer