Tbio PAN2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2

Protein Summary

Description

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q504Q3
• O75189
• Q76E12
• Q8IVE1

Gene Name

• PAN2

Ensembl ID

• ENST00000257931
• ENSP00000257931
• ENSG00000135473
• ENST00000425394
• ENSP00000401721
• ENST00000440411
• ENSP00000388231
• ENST00000548043
• ENSP00000449861
• ENST00000610546
• ENSP00000481859

Symbol

• KIAA0710
• USP52
• USP52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
protein domain	0.92
transcription factor binding site profile	0.91
histone modification site profile	0.88
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Exoribonuclease / Pan2-pan3 Deadenylation Complex Catalytic Subunit Pan2

Protein / Nucleic Acid Binding / Rna Binding Protein / Exoribonuclease / Pan2-pan3 Deadenylation Complex Catalytic Subunit Pan2

Protein / Hydrolase / Protease / Cysteine Protease / Pan2-pan3 Deadenylation Complex Catalytic Subunit Pan2

Protein / Hydrolase / Esterase / Pan2-pan3 Deadenylation Complex Catalytic Subunit Pan2

DTO Classes

Protein / Enzyme / Nuclease / Exoribonuclease / Pan2-pan3 Deadenylation Complex Catalytic Subunit Pan2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.32   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.32   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0