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Tdark
VWA3B
von Willebrand factor A domain-containing protein 3B

Protein Summary
Description
This gene encodes an intracellular protein that contains a von Willebrand factor type A domain. Intracellular proteins with VWA domains are thought to function in transcription, DNA repair, ribosomal and membrane transport and the proteasome. Mutations in this gene are associated with Spinocerebellar ataxia, autosomal recessive 22. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433678
  • ENSP00000388158
  • ENSG00000168658
  • ENST00000477737
  • ENSP00000417955
  • ENST00000614454
  • ENSP00000484764

Symbol
  • SCAR22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.95
histone modification site profile
0.66
tissue sample
0.66
trait
0.61
phenotype
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
19.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
19.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor A domain containing 3B
VGNC:412
459430
Macaque
von Willebrand factor A domain containing 3B
707760
Dog
von Willebrand factor A domain containing 3B
VGNC:48321
474564
Horse
von Willebrand factor A domain containing 3B
VGNC:24953
100061406
Cow
von Willebrand factor A domain containing 3B
VGNC:50129
536340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor A domain containing 3B
Macaque
von Willebrand factor A domain containing 3B
Dog
von Willebrand factor A domain containing 3B
Horse
von Willebrand factor A domain containing 3B
Cow
von Willebrand factor A domain containing 3B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q502W6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (31)
1 – 10 of 31
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
p_int: 0.958430635
p_ni: 0.041569365
Score: 0.239
Data Source: BioPlex,STRINGDB
INA
Tbio
Novelty: 0.00708581
p_int: 0.924586118
p_ni: 0.072511354
p_wrong: 0.002902528
Score: 0.219
Data Source: BioPlex,STRINGDB
BTBD9
Tbio
Novelty: 0.02793632
Score: 0.581
Data Source: STRINGDB
FAHD2B
Tdark
Family: Enzyme
Novelty: 1.47557507
Score: 0.565
Data Source: STRINGDB
FAM178B
Tdark
Novelty: 3.72734051
Score: 0.562
Data Source: STRINGDB
DNAH8
Tbio
Novelty: 0.10883442
Score: 0.558
Data Source: STRINGDB
FAHD2A
Tdark
Family: Enzyme
Novelty: 0.68981789
Score: 0.555
Data Source: STRINGDB
CFAP47
Tdark
Novelty: 0.59170159
Score: 0.537
Data Source: STRINGDB
SH3TC2
Tbio
Novelty: 0.0205934
Score: 0.52
Data Source: STRINGDB
ITPRIPL1
Tdark
Novelty: 3.09953366
Score: 0.52
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.24

PubMed score by year
PubTator Score  2.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer