Tdark TIGD2 Tigger transposable element-derived protein 2

Protein Summary

Description

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q4W5G0

Gene Name

• TIGD2

Ensembl ID

• ENST00000317005
• ENSP00000317170
• ENSG00000180346
• ENST00000603357
• ENSP00000486687

Symbol

• HEL106

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
transcription factor binding site profile	0.69
histone modification site profile	0.62
protein domain	0.58
tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

MEGF9

Tdark

Novelty:  0.27835989

Score:  0.583

Data Source:  STRINGDB

ZNF780A

Tdark

Family:  TF

Novelty:  2.95830815

Score:  0.574

Data Source:  STRINGDB

WASHC3

Tdark

Novelty:  0.18307321

Score:  0.571

Data Source:  STRINGDB

C19orf47

Tdark

Novelty:  21.77319588

Score:  0.559

Data Source:  STRINGDB

GPRIN3

Tbio

Novelty:  0.15509625

Score:  0.556

Data Source:  STRINGDB

C19orf54

Tdark

Novelty:  3.38332443

Score:  0.55

Data Source:  STRINGDB

JRKL

Tdark

Novelty:  0.82260428

Score:  0.534

Data Source:  STRINGDB

ZNF546

Tdark

Family:  TF

Novelty:  2.34374774

Score:  0.533

Data Source:  STRINGDB

TTC9B

Tdark

Novelty:  0.25942345

Score:  0.519

Data Source:  STRINGDB

TMEM91

Tdark

Novelty:  0.60497858

Score:  0.518

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Functions (1)

Components (1)

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GO Term	Evidence	Assigned by
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2	1	2		70.9
urate measurement	EFO_0004531	1	1	1		60.5
BMI-adjusted waist circumference	EFO_0007789	1	1	1		24.5
waist circumference	EFO_0004342	1	1	1		17.8
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		0.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2		70.9
urate measurement	EFO_0004531	1		60.5
BMI-adjusted waist circumference	EFO_0007789	1		24.5
waist circumference	EFO_0004342	1		17.8
BMI-adjusted waist-hip ratio	EFO_0007788	1		0.2

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UniProt Keyword Find Similar Targets

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Complete proteome
DNA-binding
Nucleus
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

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BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
mean platelet volume
urate measurement
waist circumference

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	tigger transposable element derived 2	MGI:1915390	68140
Rat	tigger transposable element derived 2	RGD:1559612	100912924
Dog	tigger transposable element derived 2	VGNC:47369	100856103
Opossum	tigger transposable element derived 2		100618011

Species	Name	OMA	EggNOG	Inparanoid
Mouse	tigger transposable element derived 2
Rat	tigger transposable element derived 2
Dog	tigger transposable element derived 2
Opossum	tigger transposable element derived 2

Publication Statistics

PubMed Score 1.98

PubMed score by year

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Related Publications

Text Mined References (6)

Items per page:

10

0 of 0

PMID	Year	Title