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Tdark
TIGD2
Tigger transposable element-derived protein 2

Protein Summary
Description
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317005
  • ENSP00000317170
  • ENSG00000180346
  • ENST00000603357
  • ENSP00000486687

Symbol
  • HEL106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor binding site profile
0.69
histone modification site profile
0.62
protein domain
0.58
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
MEGF9
Tdark
Novelty:  0.27835989
Score:  0.583
Data Source:  STRINGDB
ZNF780A
Tdark
Family:  TF
Novelty:  2.95830815
Score:  0.574
Data Source:  STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
Score:  0.571
Data Source:  STRINGDB
C19orf47
Tdark
Novelty:  21.77319588
Score:  0.559
Data Source:  STRINGDB
GPRIN3
Tbio
Novelty:  0.15509625
Score:  0.556
Data Source:  STRINGDB
C19orf54
Tdark
Novelty:  3.38332443
Score:  0.55
Data Source:  STRINGDB
JRKL
Tdark
Novelty:  0.82260428
Score:  0.534
Data Source:  STRINGDB
ZNF546
Tdark
Family:  TF
Novelty:  2.34374774
Score:  0.533
Data Source:  STRINGDB
TTC9B
Tdark
Novelty:  0.25942345
Score:  0.519
Data Source:  STRINGDB
TMEM91
Tdark
Novelty:  0.60497858
Score:  0.518
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
70.9
urate measurement
1
1
1
60.5
BMI-adjusted waist circumference
1
1
1
24.5
waist circumference
1
1
1
17.8
BMI-adjusted waist-hip ratio
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
70.9
urate measurement
1
60.5
BMI-adjusted waist circumference
1
24.5
waist circumference
1
17.8
BMI-adjusted waist-hip ratio
1
0.2
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915390
68140
Rat
RGD:1559612
100912924
Dog
tigger transposable element derived 2
VGNC:47369
100856103
Opossum
tigger transposable element derived 2
100618011
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tigger transposable element derived 2
Opossum
tigger transposable element derived 2
Publication Statistics
PubMed Score 1.98
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title