Protein Summary
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000304758
- ENSP00000305557
- ENSG00000126016
- ENST00000371959
- ENSP00000361027
- ENST00000524145
- ENSP00000429013
- KIAA1071
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
kinase perturbation | 0.81 | ||
PubMedID | 0.77 | ||
transcription factor perturbation | 0.74 | ||
histone modification site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 104.72 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 399 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 104.72 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 399 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
ALOX5
Family: Enzyme
Novelty: 0.00062988
p_int: 0.991228852
p_ni: 0.008771148
Score: 0.313
Data Source: BioPlex,STRINGDB
MPP5
Novelty: 0.01707773
p_int: 0.990665455
p_ni: 0.009334545
Score: 0.975
Data Source: BioPlex,STRINGDB
RAB3IL1
Novelty: 0.0167537
p_int: 0.979502277
p_ni: 0.020497723
Score: 0.188
Data Source: BioPlex,STRINGDB
WWP2
Family: Enzyme
Novelty: 0.01935799
p_int: 0.923091714
p_ni: 0.076908286
Score: 0.253
Data Source: BioPlex,STRINGDB
MED4
Family: Enzyme
Novelty: 0.01200585
p_int: 0.853992256
p_ni: 0.146007744
Data Source: BioPlex
RNF166
Novelty: 0.71460884
p_int: 0.848522817
p_ni: 0.151477183
Score: 0.181
Data Source: BioPlex,STRINGDB
MAGEA4
Novelty: 0.00949096
p_int: 0.84660737
p_ni: 0.15339263
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (60)
Reactome (2)
KEGG (2)
WikiPathways (56)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hippo | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by Hippo | ||||
Viral Interactions (0)
Gene Ontology Terms (36)
Functions (2)
Components (14)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 1 | 1 | 14.1 | |||||
hematocrit | 1 | 1 | 1 | 14 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 14.1 | |||||
hematocrit | 1 | 14 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | angiomotin | VGNC:1492 | 465814 | |||||
Macaque | angiomotin | 707701 | ||||||
Mouse | MGI:108440 | 27494 | ||||||
Rat | RGD:1564027 | 300289 | ||||||
Dog | angiomotin | VGNC:37835 | 481022 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | angiomotin | |||||
Macaque | angiomotin | |||||
Mouse | ||||||
Rat | ||||||
Dog | angiomotin | |||||
Publication Statistics
PubMed Score 104.72
PubMed score by year
PubTator Score 25.10
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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