You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
SLC22A6
Solute carrier family 22 member 6

Protein Summary
Description
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360421
  • ENSP00000353597
  • ENSG00000197901
  • ENST00000377871
  • ENSP00000367102
  • ENST00000421062
  • ENSP00000404441
  • ENST00000458333
  • ENSP00000396401

Symbol
  • OAT1
  • PAHT
  • OAT1
  • PAHT
  • HOAT1
  • ROAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug
1
chemical
0.96
molecular function
0.76
gene perturbation
0.69


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.68   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.68   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
probenecid
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
2
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
74.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 6
VGNC:7752
451273
Macaque
solute carrier family 22 member 6
718377
Mouse
MGI:892001
18399
Rat
RGD:69338
29509
Dog
solute carrier family 22 member 6
VGNC:46280
476050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 6
Macaque
solute carrier family 22 member 6
Mouse
Rat
Dog
solute carrier family 22 member 6
Pathways (5)
Organic anion transport (R-HSA-561048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic anion transport
Reactome
Organic cation/anion/zwitterion transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic anion transport
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (73)
1 – 10 of 73
SLC25A23
Tbio
Family: Transporter
Novelty: 0.10446757
p_int: 0.998156697
p_ni: 0.001841909
p_wrong: 0.000001394
Score: 0.172
Data Source: BioPlex,STRINGDB
SLC25A46
Tbio
Family: Transporter
Novelty: 0.02720146
p_int: 0.995095442
p_ni: 0.004904558
Score: 0.296
Data Source: BioPlex,STRINGDB
SLC20A2
Tbio
Family: Transporter
Novelty: 0.00387767
p_int: 0.989761004
p_ni: 0.007146941
p_wrong: 0.003092055
Score: 0.497
Data Source: BioPlex,STRINGDB
SLC25A24
Tbio
Family: Transporter
Novelty: 0.06151955
p_int: 0.982508599
p_ni: 0.017490392
p_wrong: 0.000001009
Score: 0.172
Data Source: BioPlex,STRINGDB
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
p_int: 0.961721022
p_ni: 0.038278965
p_wrong: 1.3e-8
Data Source: BioPlex
GK
Tbio
Family: Kinase
Novelty: 0.00617547
p_int: 0.954571226
p_ni: 0.045428774
Data Source: BioPlex
RAB32
Tbio
Family: Enzyme
Novelty: 0.02514559
p_int: 0.945211408
p_ni: 0.053477724
p_wrong: 0.001310868
Data Source: BioPlex
SLC38A7
Tdark
Family: Transporter
Novelty: 0.24353276
p_int: 0.932305159
p_ni: 0.000348787
p_wrong: 0.067346054
Score: 0.19
Data Source: BioPlex,STRINGDB
ERGIC3
Tbio
Novelty: 0.11095443
p_int: 0.927824614
p_ni: 0.072175384
p_wrong: 1e-9
Score: 0.53
Data Source: BioPlex,STRINGDB
ERGIC2
Tbio
Novelty: 0.08610944
p_int: 0.921003231
p_ni: 0.078990081
p_wrong: 0.000006687
Score: 0.195
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  268.68

PubMed score by year
PubTator Score  186.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: