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Tdark
MRPL51
39S ribosomal protein L51, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229238
  • ENSP00000229238
  • ENSG00000111639

Symbol
  • MRP64
  • CDA09
  • MRP64
  • bMRP64
  • HSPC241
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
cell type or tissue
0.92
kinase perturbation
0.91
small molecule perturbation
0.81
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999961287
p_ni:  0.000032567
p_wrong:  0.000006146
Score:  0.985
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.999952329
p_ni:  0.000047665
p_wrong:  6e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.999949933
p_ni:  0.000049934
p_wrong:  1.33e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.999933844
p_ni:  0.000066155
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.999929023
p_ni:  0.000070977
Score:  0.994
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999883434
p_ni:  0.00011655
p_wrong:  1.6e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL10
Tbio
Novelty:  0.27087019
p_int:  0.999728915
p_ni:  0.000271079
p_wrong:  6e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.999621037
p_ni:  0.000378961
p_wrong:  2e-9
Data Source:  BioPlex
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.999607442
p_ni:  0.000392556
p_wrong:  2e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.999601464
p_ni:  0.000398536
p_wrong:  1e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
4
96
neutrophil percentage of leukocytes
2
2
2
85.2
lymphocyte percentage of leukocytes
2
2
3
82.7
platelet crit
2
2
2
82.7
2
2
0
1.1
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
96
neutrophil percentage of leukocytes
2
85.2
lymphocyte percentage of leukocytes
3
82.7
platelet crit
2
82.7
0
1.1
73.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L51
VGNC:5487
451782
Macaque
mitochondrial ribosomal protein L51
713036
Mouse
MGI:1913743
66493
Rat
RGD:1306686
297601
Dog
mitochondrial ribosomal protein L51
VGNC:43404
100687415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L51
Macaque
mitochondrial ribosomal protein L51
Mouse
Rat
Dog
mitochondrial ribosomal protein L51
Publication Statistics
PubMed Score 3.85
PubMed score by year
PubTator Score 1.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title