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Tdark
DEFB134
Beta-defensin 134

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382205
  • ENSP00000371640
  • ENSG00000205882
  • ENST00000526438
  • ENSP00000435010
  • ENST00000645046
  • ENSP00000494837
  • ENSG00000284754
  • ENST00000646417
  • ENSP00000495848
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.47
biological term
0.33
pathway
0.32
cell line
0.31
disease
0.29


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
65.6
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (31)
1 – 10 of 31
DEFB135
Tdark
Novelty: 2.04107063
Score: 0.978
Data Source: STRINGDB
DEFB114
Tbio
Novelty: 0.22206668
Score: 0.964
Data Source: STRINGDB
DEFB128
Tbio
Novelty: 0.30093411
Score: 0.961
Data Source: STRINGDB
DEFB125
Tdark
Novelty: 0.69005738
Score: 0.961
Data Source: STRINGDB
DEFB124
Tbio
Novelty: 1.65330827
Score: 0.961
Data Source: STRINGDB
DEFB1
Tbio
Novelty: 0.00144458
Score: 0.906
Data Source: STRINGDB
DEFB136
Tdark
Score: 0.902
Data Source: STRINGDB
DEFB113
Tdark
Novelty: 0.54376643
Score: 0.902
Data Source: STRINGDB
DEFB127
Tbio
Novelty: 0.18126756
Score: 0.902
Data Source: STRINGDB
DEFB110
Tdark
Novelty: 0.49548192
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.87

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer