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Tbio
PLCH1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334686
  • ENSP00000335469
  • ENSG00000114805
  • ENST00000340059
  • ENSP00000345988
  • ENST00000447496
  • ENSP00000402759
  • ENST00000494598
  • ENSP00000419100

Symbol
  • KIAA1069
  • PLCL3
  • PLCL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
metabolite
0.89
trait
0.75
molecular function
0.63
gene perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
6.8
50.6
serum alanine aminotransferase measurement
2
2
1
5.8
50.6
alkaline phosphatase measurement
1
1
0
6.3
42.3
alcohol consumption measurement
2
1
2
36.9
total cholesterol measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
6.8
50.6
serum alanine aminotransferase measurement
1
5.8
50.6
alkaline phosphatase measurement
0
6.3
42.3
alcohol consumption measurement
2
36.9
total cholesterol measurement
1
36.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C eta 1
VGNC:2509
460795
Macaque
phospholipase C eta 1
707243
Mouse
MGI:2683547
269437
Rat
RGD:1561991
310463
Dog
phospholipase C eta 1
VGNC:44653
100684810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C eta 1
Macaque
phospholipase C eta 1
Mouse
Rat
Dog
phospholipase C eta 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q4KWH8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Protein-Protein Interactions (42)
1 – 10 of 42
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.99984698
p_ni:  0.000148762
p_wrong:  0.000004257
Data Source:  BioPlex
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.999605689
p_ni:  0.000392744
p_wrong:  0.000001567
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.99877359
p_ni:  0.001154291
p_wrong:  0.00007212
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.986990844
p_ni:  0.000027852
p_wrong:  0.012981304
Data Source:  BioPlex
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.962222215
p_ni:  0.000217847
p_wrong:  0.037559938
Data Source:  BioPlex
ETFB
Tchem
Novelty:  0.02010772
p_int:  0.817349092
p_ni:  0.001671647
p_wrong:  0.180979261
Score:  0.232
Data Source:  BioPlex,STRINGDB
PIP5KL1
Tbio
Family:  Enzyme
Novelty:  0.15208771
Score:  0.947
Data Source:  STRINGDB
PIP5K1C
Tchem
Family:  Kinase
Novelty:  0.0323077
Score:  0.935
Data Source:  STRINGDB
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
Score:  0.934
Data Source:  STRINGDB
PIP5K1B
Tbio
Family:  Kinase
Novelty:  0.05013433
Score:  0.931
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.48

PubMed score by year
PubTator Score  3.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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