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Tbio
ANO6
Anoctamin-6

Protein Summary
Description
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylseri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320560
  • ENSP00000320087
  • ENSG00000177119
  • ENST00000423947
  • ENSP00000409126
  • ENST00000425752
  • ENSP00000391417
  • ENST00000441606
  • ENSP00000413137

Symbol
  • TMEM16F
  • SCTS
  • BDPLT7
  • TMEM16F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
molecular function
0.96
transcription factor binding site profile
0.96
microRNA
0.9
transcription factor
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.87   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.87   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
35
1
1
0
1.3
21.5
waist-hip ratio
1
1
1
5.4
BMI-adjusted waist-hip ratio
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
35
0
1.3
21.5
waist-hip ratio
1
5.4
BMI-adjusted waist-hip ratio
1
5.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anoctamin 6
VGNC:8323
451845
Macaque
anoctamin 6
701540
Mouse
MGI:2145890
105722
Dog
anoctamin 6
VGNC:37929
486597
Horse
anoctamin 6
VGNC:15355
100055262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anoctamin 6
Macaque
anoctamin 6
Mouse
Dog
anoctamin 6
Horse
anoctamin 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q4KMQ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Neutrophil degranulation
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Neutrophil degranulation
Stimuli-sensing channels
Gene Ontology Terms (41)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (208)
1 – 10 of 208
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999983553
p_ni:  0.000016447
Score:  0.211
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999911639
p_ni:  0.000088361
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.999502373
p_ni:  0.000497627
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999479044
p_ni:  0.000477049
p_wrong:  0.000043907
Data Source:  BioPlex
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.999395078
p_ni:  0.000604922
Data Source:  BioPlex
ANAPC4
Tbio
Family:  Enzyme
Novelty:  0.28937094
p_int:  0.999037383
p_ni:  0.00096261
p_wrong:  7e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.997236249
p_ni:  0.002742871
p_wrong:  0.00002088
Data Source:  BioPlex
CDC23
Tbio
Novelty:  0.0168525
p_int:  0.994611728
p_ni:  0.005378514
p_wrong:  0.000009758
Data Source:  BioPlex
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.994351075
p_ni:  0.005648925
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.99334866
p_ni:  0.006651307
p_wrong:  3.3e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  500.87

PubMed score by year
PubTator Score  47.76

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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