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Tbio
TBC1D10B
TBC1 domain family member 10B

Protein Summary
Description
Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A. Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
interacting protein
0.71
co-expressed gene
0.69
tissue sample
0.63
ligand (protein) perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
ZYX
Tbio
Novelty:  0.00375452
p_int:  0.950228885
p_ni:  0.049771115
Score:  0.409
Data Source:  BioPlex,STRINGDB
RAB35
Tbio
Family:  Enzyme
Novelty:  0.01514601
Score:  0.976
Data Source:  STRINGDB
RAB22A
Tbio
Family:  Enzyme
Novelty:  0.02344687
Score:  0.748
Data Source:  STRINGDB
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
Score:  0.714
Data Source:  STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.692
Data Source:  STRINGDB
C16orf58
Tdark
Novelty:  0.34461652
Score:  0.688
Data Source:  STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
Score:  0.688
Data Source:  STRINGDB
NSF
Tbio
Family:  Enzyme
Novelty:  0.00173489
Score:  0.664
Data Source:  STRINGDB
CDC16
Tbio
Novelty:  0.00916715
Score:  0.658
Data Source:  STRINGDB
EIF3K
Tbio
Novelty:  0.04938688
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sodium measurement
2
2
2
56.6
monocyte count
2
1
2
39.4
eosinophil count
1
1
1
29
electrocardiography
1
1
2
26.1
basophil count
2
1
2
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sodium measurement
2
56.6
monocyte count
2
39.4
eosinophil count
1
29
electrocardiography
2
26.1
basophil count
2
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 10B
VGNC:5929
454041
Macaque
TBC1 domain family member 10B
711696
Mouse
MGI:1915699
68449
Rat
RGD:1309191
365372
Horse
TBC1 domain family member 10B
VGNC:23894
100063852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 10B
Macaque
TBC1 domain family member 10B
Mouse
Rat
Horse
TBC1 domain family member 10B
Publication Statistics
PubMed Score 1.95
PubMed score by year
PubTator Score 0.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title