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Tbio
CDON
Cell adhesion molecule-related/down-regulated by oncogenes

Protein Summary
Description
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263577
  • ENSP00000263577
  • ENSG00000064309
  • ENST00000392693
  • ENSP00000376458

Symbol
  • CDO
  • CDO
  • CDON1
  • HPE11
  • ORCAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
protein domain
0.85
microRNA
0.75
small molecule perturbation
0.75
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
51.2
tooth eruption
1
1
1
25.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
51.2
tooth eruption
1
25.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell adhesion associated, oncogene regulated
VGNC:3141
451650
Macaque
cell adhesion associated, oncogene regulated
714039
Mouse
MGI:1926387
57810
Rat
RGD:708433
50938
Dog
cell adhesion associated, oncogene regulated
VGNC:39076
489296
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell adhesion associated, oncogene regulated
Macaque
cell adhesion associated, oncogene regulated
Mouse
Rat
Dog
cell adhesion associated, oncogene regulated
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Developmental Biology
Reactome
Hedgehog 'on' state
Reactome
Ligand-receptor interactions
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Activation of SMO
Developmental Biology
Hedgehog 'on' state
Ligand-receptor interactions
Myogenesis
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
TNFSF8
Tbio
Novelty: 0.01292216
p_int: 0.999999063
p_ni: 9.37e-7
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.999971181
p_ni: 0.000028814
p_wrong: 5e-9
Score: 0.182
Data Source: BioPlex,STRINGDB
PCDH12
Tbio
Novelty: 0.06268895
p_int: 0.999942382
p_ni: 0.00005754
p_wrong: 7.8e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
CEACAM21
Tdark
Novelty: 0.46116153
p_int: 0.999941794
p_ni: 0.00005554
p_wrong: 0.000002666
Score: 0.201
Data Source: BioPlex,STRINGDB
PVR
Tbio
Novelty: 0.00215811
p_int: 0.999683458
p_ni: 0.000148361
p_wrong: 0.000168181
Score: 0.164
Data Source: BioPlex,STRINGDB
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.996782646
p_ni: 0.003183695
p_wrong: 0.000033659
Data Source: BioPlex
DHH
Tbio
Novelty: 0.00329784
Score: 0.991
Data Source: STRINGDB
PTCH1
Tbio
Novelty: 0.00077635
Score: 0.978
Data Source: Reactome,STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.972
Data Source: Reactome,STRINGDB
CDH2
Tbio
Novelty: 0.00040112
Score: 0.967
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  227.03

PubMed score by year
PubTator Score  159.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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