Tdark PTPN20 Tyrosine-protein phosphatase non-receptor type 20

Protein Summary

Description

Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates. The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q4JDL3
• A6NNH8
• B7ZKV3
• Q4JDG6
• Q4JDK1
• Q4JDK5
• Q4JDK6
• Q4JDK8
• Q4JDK9
• Q4JDL0
• Q4JDL1
• Q4JDL4
• Q4JDL5
• Q4JDL6
• Q4JDL7
• Q4JDL8
• Q5RJ33
• Q5T1G3
• hPTPN20

Gene Name

• PTPN20

Ensembl ID

• ENST00000374218
• ENSP00000363335
• ENSG00000204179
• ENST00000374339
• ENSP00000363459
• ENST00000374346
• ENSP00000363466
• ENST00000395721
• ENSP00000379071
• ENST00000395725
• ENSP00000379075
• ENST00000395727
• ENSP00000379077
• ENST00000502254
• ENSP00000421404
• ENST00000502705
• ENSP00000420995
• ENST00000503851
• ENSP00000427676
• ENST00000505814
• ENSP00000426355
• ENST00000506080
• ENSP00000421921
• ENST00000508602
• ENSP00000424491
• ENST00000509599
• ENSP00000425012
• ENST00000509774
• ENSP00000425362
• ENST00000509900
• ENSP00000423819
• ENST00000510335
• ENSP00000421453
• ENST00000511769
• ENSP00000424283
• ENST00000513156
• ENSP00000425912
• ENST00000513266
• ENSP00000422839

Symbol

• PTPN20A
• PTPN20B
• CT126
• PTPN20A
• PTPN20B
• bA42B19.1
• bA142I17.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
tissue sample	0.75
co-expressed gene	0.69
microRNA	0.63
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.27   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.27   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0