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Tchem
PREPL
Prolyl endopeptidase-like

Protein Summary
Description
Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regulation of synaptic vesiscle exocytosis (PubMed:24610330). The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260648
  • ENSP00000260648
  • ENSG00000138078
  • ENST00000378511
  • ENSP00000367772
  • ENST00000378520
  • ENSP00000367781
  • ENST00000409272
  • ENSP00000386909
  • ENST00000409411
  • ENSP00000387095
  • ENST00000409936
  • ENSP00000386543
  • ENST00000409957
  • ENSP00000387241
  • ENST00000410081
  • ENSP00000386509
  • ENST00000425263
  • ENSP00000391456
  • ENST00000426481
  • ENSP00000409480
  • ENST00000541738
  • ENSP00000439626

Symbol
  • KIAA0436
  • CMS22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.97
disease perturbation
0.9
histone modification site profile
0.87
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.06   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.06   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
85
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolyl endopeptidase like
VGNC:50340
737963
Macaque
prolyl endopeptidase-like
713980
Mouse
MGI:2441932
213760
Rat
RGD:1310143
298771
Dog
prolyl endopeptidase like
VGNC:44961
474574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolyl endopeptidase like
Macaque
prolyl endopeptidase-like
Mouse
Rat
Dog
prolyl endopeptidase like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q4J6C6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (72)
1 – 10 of 72
MRPL41
Tbio
Novelty: 0.04024303
p_int: 0.999957214
p_ni: 0.000042786
Data Source: BioPlex
ARHGAP36
Tbio
Family: Enzyme
Novelty: 0.33342126
p_int: 0.999951682
p_ni: 0.000048318
Score: 0.178
Data Source: BioPlex,STRINGDB
GATD1
Tdark
Family: Enzyme
Novelty: 0.40291197
p_int: 0.999921792
p_ni: 0.000078208
Data Source: BioPlex
LIG3
Tbio
Family: Enzyme
Novelty: 0.00809038
p_int: 0.993724916
p_ni: 0.006275084
Score: 0.232
Data Source: BioPlex,STRINGDB
ODAPH
Tbio
Novelty: 0.20386223
p_int: 0.987129242
p_ni: 0.012870758
Data Source: BioPlex
SLIRP
Tbio
Novelty: 0.04630917
p_int: 0.982197613
p_ni: 0.017802387
Data Source: BioPlex
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.975136081
p_ni: 0.024863919
Data Source: BioPlex
YBEY
Tdark
Family: Enzyme
Novelty: 0.02778029
p_int: 0.946375693
p_ni: 0.053624307
Score: 0.176
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.933888208
p_ni: 0.066111792
Data Source: BioPlex
SDHB
Tbio
Family: Enzyme
Novelty: 0.0010199
p_int: 0.908125385
p_ni: 0.091874615
Score: 0.184
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  46.06

PubMed score by year
PubTator Score  21.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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