Tbio KCTD21 BTB/POZ domain-containing protein KCTD21

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd21

DTO Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd21

Protein Summary

Description

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Uniprot Accession IDs

• Q4G0X4
• B4DTR0

Gene Name

• KCTD21

Ensembl ID

• ENST00000340067
• ENSP00000339340
• ENSG00000188997

Symbol

• KCASH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
tissue sample	0.63
cell line	0.57
microRNA	0.54
transcription factor binding site profile	0.49

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	potassium channel tetramerisation domain containing 21	MGI:3643121	622320
Dog	potassium channel tetramerization domain containing 21	VGNC:52263	608875
Horse	potassium channel tetramerization domain containing 21	VGNC:19324	100062932
Cow	potassium channel tetramerization domain containing 21	VGNC:30511	539645
Opossum	potassium channel tetramerization domain containing 21		100017978

Species	Name	OMA	EggNOG	Inparanoid
Mouse	potassium channel tetramerisation domain containing 21
Dog	potassium channel tetramerization domain containing 21
Horse	potassium channel tetramerization domain containing 21
Cow	potassium channel tetramerization domain containing 21
Opossum	potassium channel tetramerization domain containing 21

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q4G0X4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)

UniProt (1)

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Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
UniProt	Protein modification; protein ubiquitination.	399 targets

Name	Explore in Pharos	Explore in Source
Protein modification; protein ubiquitination.	399 targets

Gene Ontology Terms (8)

Functions (3)

Processes (5)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cullin family protein binding	Inferred from Direct Assay (IDA)	UniProtKB
histone deacetylase binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

DNAJB11

Tbio

Novelty: 0.02588745

p_int: 0.999995113

p_ni: 0.000004887

Score: 0.198

Data Source: BioPlex,STRINGDB

DOC2A

Tbio

Novelty: 0.07489914

p_int: 0.999988799

p_ni: 0.000011164

p_wrong: 3.7e-8

Score: 0.28

Data Source: BioPlex,STRINGDB

KLHL14

Tbio

Novelty: 0.1214402

p_int: 0.999973539

p_ni: 0.00001625

p_wrong: 0.000010211

Score: 0.28

Data Source: BioPlex,STRINGDB

MRGBP

Tbio

Novelty: 0.09537142

p_int: 0.999964778

p_ni: 0.00003522

p_wrong: 2e-9

Data Source: BioPlex

WDFY1

Tbio

Novelty: 0.13382544

p_int: 0.999958216

p_ni: 0.000041764

p_wrong: 2e-8

Score: 0.167

Data Source: BioPlex,STRINGDB

TNFAIP6

Tbio

Novelty: 0.0046811

p_int: 0.999948151

p_ni: 0.000049994

p_wrong: 0.000001855

Data Source: BioPlex

ANKRD39

Tdark

Novelty: 8.68843298

p_int: 0.999929655

p_ni: 0.000068746

p_wrong: 0.000001599

Data Source: BioPlex

LILRB3

Tbio

Novelty: 0.01370238

p_int: 0.999692989

p_ni: 0.000109661

p_wrong: 0.00019735

Score: 0.243

Data Source: BioPlex,STRINGDB

TRIB2

Tbio

Family: Kinase

Novelty: 0.02240668

p_int: 0.999405689

p_ni: 0.000144591

p_wrong: 0.00044972

Score: 0.171

Data Source: BioPlex,STRINGDB

C10orf91

Tdark

p_int: 0.998025271

p_ni: 0.000091107

p_wrong: 0.001883621

Data Source: BioPlex

Publication Statistics

PubMed Score  0.98

PubMed score by year

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PubTator Score  0.59

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Coiled coil
Complete proteome
Growth regulation
Reference proteome
Tumor suppressor
Ubl conjugation pathway