Tbio KCTD21 BTB/POZ domain-containing protein KCTD21

Protein Summary

Description

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Uniprot Accession IDs

• Q4G0X4
• B4DTR0

Gene Name

• KCTD21

Ensembl ID

• ENST00000340067
• ENSP00000339340
• ENSG00000188997

Symbol

• KCASH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
tissue sample	0.63
cell line	0.57
microRNA	0.54
transcription factor binding site profile	0.49

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd21

DTO Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.48   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.48   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

DNAJB11

Tbio

Novelty:  0.02588745

p_int:  0.999995113

p_ni:  0.000004887

Score:  0.198

Data Source:  BioPlex,STRINGDB

DOC2A

Tbio

Novelty:  0.07489914

p_int:  0.999988799

p_ni:  0.000011164

p_wrong:  3.7e-8

Score:  0.28

Data Source:  BioPlex,STRINGDB

KLHL14

Tbio

Novelty:  0.1214402

p_int:  0.999973539

p_ni:  0.00001625

p_wrong:  0.000010211

Score:  0.28

Data Source:  BioPlex,STRINGDB

MRGBP

Tbio

Novelty:  0.09537142

p_int:  0.999964778

p_ni:  0.00003522

p_wrong:  2e-9

Data Source:  BioPlex

WDFY1

Tbio

Novelty:  0.13382544

p_int:  0.999958216

p_ni:  0.000041764

p_wrong:  2e-8

Score:  0.167

Data Source:  BioPlex,STRINGDB

TNFAIP6

Tbio

Novelty:  0.0046811

p_int:  0.999948151

p_ni:  0.000049994

p_wrong:  0.000001855

Data Source:  BioPlex

ANKRD39

Tdark

Novelty:  8.68843298

p_int:  0.999929655

p_ni:  0.000068746

p_wrong:  0.000001599

Data Source:  BioPlex

LILRB3

Tbio

Novelty:  0.01370238

p_int:  0.999692989

p_ni:  0.000109661

p_wrong:  0.00019735

Score:  0.243

Data Source:  BioPlex,STRINGDB

TRIB2

Tbio

Family:  Kinase

Novelty:  0.02240668

p_int:  0.999405689

p_ni:  0.000144591

p_wrong:  0.00044972

Score:  0.171

Data Source:  BioPlex,STRINGDB

C10orf91

Tdark

p_int:  0.998025271

p_ni:  0.000091107

p_wrong:  0.001883621

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

UniProt (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
UniProt	Protein modification; protein ubiquitination.	399 targets

Name	Explore in Pharos	Explore in Source
Protein modification; protein ubiquitination.	399 targets

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (3)

Processes (5)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
cullin family protein binding	Inferred from Direct Assay (IDA)	UniProtKB
histone deacetylase binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Disease Associations ()

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
total cholesterol measurement	EFO_0004574	1	1	1		62.1
serum alanine aminotransferase measurement	EFO_0004735	2	2	1	6.2	54.2
Testicular Germ Cell Tumor	EFO_1000566	1	1	0	1.3	44.2
diastolic blood pressure	EFO_0006336	1	1	1		39.6
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		28.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
total cholesterol measurement	EFO_0004574	1		62.1
serum alanine aminotransferase measurement	EFO_0004735	1	6.2	54.2
Testicular Germ Cell Tumor	EFO_1000566	0	1.3	44.2
diastolic blood pressure	EFO_0006336	1		39.6
low density lipoprotein cholesterol measurement	EFO_0004611	1		28.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Growth regulation
Reference proteome
Tumor suppressor
Ubl conjugation pathway

GWAS Trait Find Similar Targets

No Header	No Header
creatinine measurement
diastolic blood pressure
low density lipoprotein cholesterol measurement
serum alanine aminotransferase measurement
Testicular Germ Cell Tumor
total cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	potassium channel tetramerisation domain containing 21	MGI:3643121	622320
Dog	potassium channel tetramerization domain containing 21	VGNC:52263	608875
Horse	potassium channel tetramerization domain containing 21	VGNC:19324	100062932
Cow	potassium channel tetramerization domain containing 21	VGNC:30511	539645
Opossum	potassium channel tetramerization domain containing 21		100017978

Species	Name	OMA	EggNOG	Inparanoid
Mouse	potassium channel tetramerisation domain containing 21
Dog	potassium channel tetramerization domain containing 21
Horse	potassium channel tetramerization domain containing 21
Cow	potassium channel tetramerization domain containing 21
Opossum	potassium channel tetramerization domain containing 21

Publication Statistics

PubMed Score 1.48

PubMed score by year

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PubTator Score 0.59

PubTator score by year

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Related Publications

Text Mined References (4)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title