Tbio KCTD21 BTB/POZ domain-containing protein KCTD21

Protein Summary

Description

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Uniprot Accession IDs

• Q4G0X4
• B4DTR0

Gene Name

• KCTD21

Ensembl ID

• ENST00000340067
• ENSP00000339340
• ENSG00000188997

Symbol

• KCASH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
tissue sample	0.63
cell line	0.57
microRNA	0.54
transcription factor binding site profile	0.49

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd21

DTO Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0