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Tbio
KCTD21
BTB/POZ domain-containing protein KCTD21

Protein Classes
Protein Summary
Description
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340067
  • ENSP00000339340
  • ENSG00000188997

Symbol
  • KCASH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
tissue sample
0.63
cell line
0.57
microRNA
0.54
transcription factor binding site profile
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3643121
622320
Dog
potassium channel tetramerization domain containing 21
VGNC:52263
608875
Horse
potassium channel tetramerization domain containing 21
VGNC:19324
100062932
Cow
potassium channel tetramerization domain containing 21
VGNC:30511
539645
Opossum
potassium channel tetramerization domain containing 21
100017978
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
potassium channel tetramerization domain containing 21
Horse
potassium channel tetramerization domain containing 21
Cow
potassium channel tetramerization domain containing 21
Opossum
potassium channel tetramerization domain containing 21
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q4G0X4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Protein-Protein Interactions (27)
1 – 10 of 27
DNAJB11
Tbio
Novelty: 0.02588745
p_int: 0.999995113
p_ni: 0.000004887
Score: 0.198
Data Source: BioPlex,STRINGDB
DOC2A
Tbio
Novelty: 0.07489914
p_int: 0.999988799
p_ni: 0.000011164
p_wrong: 3.7e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
KLHL14
Tbio
Novelty: 0.1214402
p_int: 0.999973539
p_ni: 0.00001625
p_wrong: 0.000010211
Score: 0.28
Data Source: BioPlex,STRINGDB
MRGBP
Tbio
Novelty: 0.09537142
p_int: 0.999964778
p_ni: 0.00003522
p_wrong: 2e-9
Data Source: BioPlex
WDFY1
Tbio
Novelty: 0.13382544
p_int: 0.999958216
p_ni: 0.000041764
p_wrong: 2e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
TNFAIP6
Tbio
Novelty: 0.0046811
p_int: 0.999948151
p_ni: 0.000049994
p_wrong: 0.000001855
Data Source: BioPlex
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.999929655
p_ni: 0.000068746
p_wrong: 0.000001599
Data Source: BioPlex
LILRB3
Tbio
Novelty: 0.01370238
p_int: 0.999692989
p_ni: 0.000109661
p_wrong: 0.00019735
Score: 0.243
Data Source: BioPlex,STRINGDB
TRIB2
Tbio
Family: Kinase
Novelty: 0.02240668
p_int: 0.999405689
p_ni: 0.000144591
p_wrong: 0.00044972
Score: 0.171
Data Source: BioPlex,STRINGDB
C10orf91
Tdark
p_int: 0.998025271
p_ni: 0.000091107
p_wrong: 0.001883621
Data Source: BioPlex
Publication Statistics
PubMed Score  0.98

PubMed score by year
PubTator Score  0.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer