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Tbio
DUSP28
Dual specificity phosphatase 28

Protein Summary
Description
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343217
  • ENSP00000344235
  • ENSG00000188542
  • ENST00000405954
  • ENSP00000385885

Symbol
  • VHP
  • DUSP26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
protein domain
0.73
tissue sample
0.69
transcription factor
0.57
histone modification site profile
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.48   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.48   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (25)
1 – 10 of 25
PIFO
Tbio
Novelty:  0.23031682
p_int:  0.918887674
p_ni:  0.000340658
p_wrong:  0.080771668
Score:  0.403
Data Source:  BioPlex,STRINGDB
JOSD2
Tbio
Novelty:  0.27109362
p_int:  0.918887674
p_ni:  0.000340658
p_wrong:  0.080771668
Score:  0.297
Data Source:  BioPlex,STRINGDB
ABLIM1
Tbio
Novelty:  0.05511373
Score:  0.8
Data Source:  STRINGDB
ABLIM3
Tdark
Novelty:  0.28184092
Score:  0.8
Data Source:  STRINGDB
ABLIM2
Tdark
Novelty:  0.23629309
Score:  0.8
Data Source:  STRINGDB
ABRA
Tbio
Novelty:  0.06200266
Score:  0.761
Data Source:  STRINGDB
CORO1C
Tbio
Novelty:  0.02068813
Score:  0.657
Data Source:  STRINGDB
VIL1
Tbio
Novelty:  0.00538607
Score:  0.654
Data Source:  STRINGDB
SVIL
Tbio
Novelty:  0.03007571
Score:  0.65
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.644
Data Source:  STRINGDB
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
2
4
96.2
platelet count
2
1
2
86.4
3
3
0
1.2
82.6
monocyte count
2
1
2
82
mean corpuscular volume
1
1
1
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
96.2
platelet count
2
86.4
0
1.2
82.6
monocyte count
2
82
mean corpuscular volume
1
81.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914696
67446
Opossum
dual specificity phosphatase 28
100027653
Platypus
dual specificity phosphatase 28
100078441
Chicken
dual specificity phosphatase 28
CGNC:236
430912
Xenopus
dual specificity phosphatase 28
XB-GENE-1000308
100135072
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Opossum
dual specificity phosphatase 28
Platypus
dual specificity phosphatase 28
Chicken
dual specificity phosphatase 28
Xenopus
dual specificity phosphatase 28
Publication Statistics
PubMed Score 36.48
PubMed score by year
PubTator Score 7.45
PubTator score by year