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Tbio
HYDIN
Hydrocephalus-inducing protein homolog

Protein Summary
Description
Required for ciliary motility. This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321489
  • ENSP00000314736
  • ENSG00000157423
  • ENST00000393567
  • ENSP00000377197
  • ENST00000538248
  • ENSP00000444970
  • ENST00000541601
  • ENSP00000437341
  • ENST00000634268
  • ENSP00000489181
  • ENSG00000283022
  • ENST00000634392
  • ENSP00000489221
  • ENST00000634745
  • ENSP00000489246
  • ENST00000635381
  • ENSP00000489526

Symbol
  • HYDIN1
  • KIAA1864
  • CILD5
  • HYDIN1
  • HYDIN2
  • PPP1R31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.68
kinase perturbation
0.6
transcription factor
0.56
histone modification site profile
0.52
microRNA
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
49.4
apolipoprotein B measurement
1
1
1
15.1
hematocrit
1
1
1
13.1
coffee consumption measurement
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
49.4
apolipoprotein B measurement
1
15.1
hematocrit
1
13.1
coffee consumption measurement
1
7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (125)
1 – 10 of 125
GPRIN2
Tbio
Novelty: 0.07888894
Score: 0.841
Data Source: STRINGDB
SRGAP2
Tbio
Family: Enzyme
Novelty: 0.02951755
Score: 0.81
Data Source: STRINGDB
SRGAP3
Tbio
Family: Enzyme
Novelty: 0.01913784
Score: 0.805
Data Source: STRINGDB
RSPH9
Tbio
Novelty: 0.08651313
Score: 0.805
Data Source: STRINGDB
NBPF1
Tdark
Novelty: 0.18226903
Score: 0.803
Data Source: STRINGDB
UGT2B17
Tbio
Family: Enzyme
Novelty: 0.0088729
Score: 0.802
Data Source: STRINGDB
NPEPPS
Tchem
Family: Enzyme
Novelty: 0.01214136
Score: 0.802
Data Source: STRINGDB
NBPF12
Tdark
Novelty: 0.01235433
Score: 0.801
Data Source: STRINGDB
RSPH4A
Tbio
Novelty: 0.07992083
Score: 0.796
Data Source: STRINGDB
CCDC39
Tbio
Novelty: 0.0150835
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.46

PubMed score by year
PubTator Score  9.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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