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Tdark
SLC9C1
Sodium/hydrogen exchanger 10

Protein Summary
Description
Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305815
  • ENSP00000306627
  • ENSG00000172139
  • ENST00000487372
  • ENSP00000420688
  • ENST00000642317
  • ENSP00000495147
  • ENSG00000285044
  • ENST00000647463
  • ENSP00000495048

Symbol
  • SLC9A10
  • NHE
  • NHE-10
  • SLC9A10
  • sperm-NHE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.68
cell line
0.61
molecular function
0.53
cellular component
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
Score:  0.815
Data Source:  STRINGDB
ADCY10
Tchem
Family:  Enzyme
Novelty:  0.00037654
Score:  0.741
Data Source:  STRINGDB
LRBA
Tbio
Novelty:  0.00093369
Score:  0.679
Data Source:  STRINGDB
SDHC
Tbio
Family:  Enzyme
Novelty:  0.0005776
Score:  0.592
Data Source:  STRINGDB
SLC9B2
Tbio
Family:  Transporter
Novelty:  0.04898001
Score:  0.577
Data Source:  STRINGDB
PNCK
Tchem
Family:  Kinase
Novelty:  0.13037374
Score:  0.569
Data Source:  STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.553
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.549
Data Source:  STRINGDB
TMCO3
Tdark
Novelty:  1.16719823
Score:  0.535
Data Source:  STRINGDB
CATSPER1
Tchem
Family:  IC
Novelty:  0.01971564
Score:  0.504
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
5
5
95.7
eosinophil percentage of leukocytes
2
4
4
94.3
neutrophil percentage of granulocytes
1
2
2
66.3
sum of eosinophil and basophil counts
1
2
2
64.8
eosinophil percentage of granulocytes
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
95.7
eosinophil percentage of leukocytes
4
94.3
neutrophil percentage of granulocytes
2
66.3
sum of eosinophil and basophil counts
2
64.8
eosinophil percentage of granulocytes
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member C1
VGNC:8844
460582
Macaque
solute carrier family 9 member C1
708000
Mouse
MGI:2685456
208169
Dog
solute carrier family 9 member C1
VGNC:46492
478563
Horse
solute carrier family 9 member C1 [Source:HGNC Symbol;Acc:HGNC:31401]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member C1
Macaque
solute carrier family 9 member C1
Mouse
Dog
solute carrier family 9 member C1
Horse
solute carrier family 9 member C1 [Source:HGNC Symbol;Acc:HGNC:31401]
Publication Statistics
PubMed Score 176.59
PubMed score by year
PubTator Score 320.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title