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Tbio
NADK2
NAD kinase 2, mitochondrial

Protein Summary
Description
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282512
  • ENSP00000282512
  • ENSG00000152620
  • ENST00000381937
  • ENSP00000371362
  • ENST00000397338
  • ENSP00000380499
  • ENST00000514504
  • ENSP00000421029

Symbol
  • C5orf33
  • MNADK
  • NADKD1
  • DECRD
  • MNADK
  • NADKD1
  • C5orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.88
protein domain
0.73
histone modification site profile
0.72
cell type or tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (27)
1 – 10 of 27
ETFRF1
Tdark
Novelty: 1.28847105
p_int: 0.936142663
p_ni: 0.063857337
Score: 0.359
Data Source: BioPlex,STRINGDB
NADK
Tbio
Family: Kinase
Novelty: 0.02812925
Score: 0.979
Data Source: STRINGDB
NNT
Tbio
Family: Enzyme
Novelty: 0.00269343
Score: 0.938
Data Source: STRINGDB
NMNAT3
Tbio
Family: Enzyme
Novelty: 0.03261313
Score: 0.938
Data Source: STRINGDB
NADSYN1
Tbio
Family: Enzyme
Novelty: 0.0445844
Score: 0.937
Data Source: STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
Score: 0.931
Data Source: STRINGDB
NMNAT2
Tbio
Family: Enzyme
Novelty: 0.01709189
Score: 0.913
Data Source: STRINGDB
NUDT12
Tbio
Family: Enzyme
Novelty: 0.18740719
Score: 0.902
Data Source: STRINGDB
ENPP3
Tbio
Family: Enzyme
Novelty: 0.00414129
Score: 0.901
Data Source: STRINGDB
BST1
Tbio
Family: Enzyme
Novelty: 0.01329061
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.33

PubMed score by year
PubTator Score  3.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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