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Tchem
LARP7
La-related protein 7

Protein Summary
Description
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324052
  • ENSP00000314311
  • ENSG00000174720
  • ENST00000344442
  • ENSP00000344950
  • ENST00000509061
  • ENSP00000422626

Symbol
  • ALAZS
  • PIP7S
  • HDCMA18P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
virus perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.85
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.35   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.35   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
alvocidib
Rendered image for alvocidib
Protein-Protein Interactions (69)
1 – 10 of 69
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.997594135
p_ni:  0.002405865
Score:  0.942
Data Source:  BioPlex,STRINGDB
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.984022199
p_ni:  0.015977801
Score:  0.901
Data Source:  BioPlex,STRINGDB
HEXIM1
Tbio
Novelty:  0.0142443
p_int:  0.977810008
p_ni:  0.022189992
Score:  0.969
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.967353228
p_ni:  0.032646772
Data Source:  BioPlex
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.951170321
p_ni:  0.048829679
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.941460265
p_ni:  0.058539735
Score:  0.391
Data Source:  BioPlex,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.929594607
p_ni:  0.070405393
Score:  0.187
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.913911215
p_ni:  0.086088785
Score:  0.497
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.910746374
p_ni:  0.089253626
Score:  0.833
Data Source:  BioPlex,STRINGDB
RPS8
Tbio
Novelty:  0.00976281
p_int:  0.908526225
p_ni:  0.091473775
Score:  0.269
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1.6
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 7
VGNC:2979
738277
Macaque
La ribonucleoprotein domain family member 7
703731
Mouse
MGI:107634
28036
Rat
RGD:1592474
686883
Dog
La ribonucleoprotein domain family member 7
VGNC:42591
478519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
La ribonucleoprotein domain family member 7
Macaque
La ribonucleoprotein domain family member 7
Mouse
Rat
Dog
La ribonucleoprotein domain family member 7
Publication Statistics
PubMed Score 39.35
PubMed score by year
PubTator Score 26.33
PubTator score by year