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Tchem
KMT5B
Histone-lysine N-methyltransferase KMT5B

Protein Summary
Description
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304363
  • ENSP00000305899
  • ENSG00000110066
  • ENST00000401547
  • ENSP00000385965
  • ENST00000405515
  • ENSP00000385640
  • ENST00000615954
  • ENSP00000484858

Symbol
  • SUV420H1
  • CGI85
  • MRD51
  • CGI-85
  • SUV420H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.07   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.07   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
A-196
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
92.1
systolic blood pressure
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
92.1
systolic blood pressure
1
4.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 5B
VGNC:7658
451378
Macaque
lysine methyltransferase 5B
710481
Mouse
MGI:2444557
225888
Rat
RGD:1311637
361688
Dog
lysine methyltransferase 5B
VGNC:42494
483690
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 5B
Macaque
lysine methyltransferase 5B
Mouse
Rat
Dog
lysine methyltransferase 5B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q4FZB7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Protein-Protein Interactions (79)
1 – 10 of 79
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.916
Data Source: STRINGDB
KMT5A
Tchem
Family: Epigenetic
Novelty: 0.01038878
Score: 0.881
Data Source: STRINGDB
SUV39H2
Tbio
Family: Epigenetic
Novelty: 0.02232167
Score: 0.814
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.809
Data Source: Reactome,STRINGDB
SUV39H1
Tchem
Family: Epigenetic
Novelty: 0.00417439
Score: 0.799
Data Source: STRINGDB
DOT1L
Tchem
Family: Epigenetic
Novelty: 0.00361358
Score: 0.795
Data Source: STRINGDB
SMYD3
Tchem
Family: Epigenetic
Novelty: 0.01040802
Score: 0.781
Data Source: STRINGDB
CAMKMT
Tbio
Family: Enzyme
Novelty: 0.00382649
Score: 0.78
Data Source: STRINGDB
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
Score: 0.764
Data Source: STRINGDB
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
Score: 0.759
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.07

PubMed score by year
PubTator Score  13.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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