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Tbio
CRY2
Cryptochrome-2

Protein Summary
Description
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417225
  • ENSP00000397419
  • ENSG00000121671
  • ENST00000616080
  • ENSP00000484684

Symbol
  • KIAA0658
  • HCRY2
  • PHLL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.9
virus perturbation
0.85
transcription factor binding site profile
0.74
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 649.88   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 649.88   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
85.7
fasting blood glucose measurement
3
1
3
76.2
body mass index
1
1
1
68.7
triglyceride measurement
1
1
1
22.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
85.7
fasting blood glucose measurement
3
76.2
body mass index
1
68.7
triglyceride measurement
1
22.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cryptochrome circadian regulator 2
VGNC:3142
742186
Macaque
cryptochrome circadian regulator 2
715000
Mouse
MGI:1270859
12953
Rat
RGD:620935
170917
Dog
cryptochrome circadian regulator 2
VGNC:39634
483641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cryptochrome circadian regulator 2
Macaque
cryptochrome circadian regulator 2
Mouse
Rat
Dog
cryptochrome circadian regulator 2
Pathways (23)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Circadian Clock
Gene Ontology Terms (25)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (104)
1 – 10 of 104
CRY1
Tchem
Novelty: 0.00116593
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
OTUD4
Tbio
Novelty: 0.17121119
p_int: 0.999997964
p_ni: 0.000002036
Data Source: BioPlex
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.99998511
p_ni: 0.00001489
Score: 0.545
Data Source: BioPlex,STRINGDB
PER1
Tbio
Novelty: 0.01290576
p_int: 0.999984285
p_ni: 0.000015715
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CSNK1D
Tchem
Family: Kinase
Novelty: 0.00896935
p_int: 0.999982271
p_ni: 0.000017729
Score: 0.994
Data Source: BioPlex,STRINGDB
TEKT4
Tbio
Novelty: 0.05559086
p_int: 0.99998127
p_ni: 0.000018725
p_wrong: 5e-9
Score: 0.71
Data Source: BioPlex,STRINGDB
FBXL3
Tbio
Novelty: 0.05042679
p_int: 0.999950282
p_ni: 0.000049718
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999884224
p_ni: 0.000115773
p_wrong: 3e-9
Data Source: BioPlex
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.999258559
p_ni: 0.00074081
p_wrong: 6.31e-7
Score: 0.305
Data Source: BioPlex,STRINGDB
SERTAD4
Tdark
Novelty: 0.70786986
p_int: 0.999146985
p_ni: 0.000001682
p_wrong: 0.000851333
Data Source: BioPlex
Publication Statistics
PubMed Score  649.88

PubMed score by year
PubTator Score  125.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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