Protein Summary
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
- ENST00000417225
- ENSP00000397419
- ENSG00000121671
- ENST00000616080
- ENSP00000484684
- KIAA0658
- HCRY2
- PHLL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.99 | ||
biological process | 0.9 | ||
virus perturbation | 0.85 | ||
transcription factor binding site profile | 0.74 | ||
microRNA | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 672.54 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 223 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 672.54 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 223 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (104)
CRY1
Novelty: 0.00116593
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
SKP1
Family: Enzyme
Novelty: 0.00149739
p_int: 0.99998511
p_ni: 0.00001489
Score: 0.545
Data Source: BioPlex,STRINGDB
PER1
Novelty: 0.01290576
p_int: 0.999984285
p_ni: 0.000015715
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CSNK1D
Family: Kinase
Novelty: 0.00896935
p_int: 0.999982271
p_ni: 0.000017729
Score: 0.994
Data Source: BioPlex,STRINGDB
TEKT4
Novelty: 0.05559086
p_int: 0.99998127
p_ni: 0.000018725
p_wrong: 5e-9
Score: 0.71
Data Source: BioPlex,STRINGDB
FBXL3
Novelty: 0.05042679
p_int: 0.999950282
p_ni: 0.000049718
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Novelty: 0.00769368
p_int: 0.999884224
p_ni: 0.000115773
p_wrong: 3e-9
Data Source: BioPlex
QPRT
Family: Enzyme
Novelty: 0.00781554
p_int: 0.999258559
p_ni: 0.00074081
p_wrong: 6.31e-7
Score: 0.305
Data Source: BioPlex,STRINGDB
SERTAD4
Novelty: 0.70786986
p_int: 0.999146985
p_ni: 0.000001682
p_wrong: 0.000851333
Data Source: BioPlex
Nearest Tclin Targets
Pathways (23)
Reactome (1)
KEGG (1)
PathwayCommons (2)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Circadian Clock | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Circadian Clock | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (7)
Components (4)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
glucose measurement | 2 | 2 | 2 | 91.9 | |||||
high density lipoprotein cholesterol measurement | 3 | 2 | 3 | 87.5 | |||||
fasting blood glucose measurement | 6 | 1 | 6 | 77.9 | |||||
3 | 3 | 2 | 1 | 71.4 | |||||
body mass index | 1 | 1 | 1 | 63.7 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
glucose measurement | 2 | 91.9 | |||||
high density lipoprotein cholesterol measurement | 3 | 87.5 | |||||
fasting blood glucose measurement | 6 | 77.9 | |||||
2 | 1 | 71.4 | |||||
body mass index | 1 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cryptochrome circadian regulator 2 | VGNC:3142 | 742186 | |||||
Macaque | cryptochrome circadian regulator 2 | 715000 | ||||||
Mouse | MGI:1270859 | 12953 | ||||||
Rat | RGD:620935 | 170917 | ||||||
Dog | cryptochrome circadian regulator 2 | VGNC:39634 | 483641 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cryptochrome circadian regulator 2 | |||||
Macaque | cryptochrome circadian regulator 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cryptochrome circadian regulator 2 | |||||
Publication Statistics
PubMed Score 672.54
PubMed score by year
PubTator Score 125.96
PubTator score by year
Related Publications
Text Mined References (90)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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