Tbio CDNF Cerebral dopamine neurotrophic factor

Protein Summary

Description

Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

Uniprot Accession IDs

• Q49AH0
• A2RUU0
• B4DVW3

Gene Name

• CDNF

Ensembl ID

• ENST00000378442
• ENSP00000367703
• ENSG00000185267
• ENST00000465530
• ENSP00000419395

Symbol

• ARMETL1
• ARMETL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
cell type or tissue	0.76
transcription factor binding site profile	0.74
microRNA	0.59
tissue sample	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.87   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.87   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0