Tdark CCDC14 Coiled-coil domain-containing protein 14

Protein Summary

Description

Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.

Uniprot Accession IDs

• Q49A88
• B7Z2Q3
• B7Z2T2
• B8ZZ41
• B8ZZ58
• D3DN98
• Q7Z3N3
• Q86T30
• Q8IWF8
• Q8WUJ8
• Q96K47
• Q9H9A3
• Q9UFH0

Gene Name

• CCDC14

Ensembl ID

• ENST00000433542
• ENSP00000395706
• ENSG00000175455
• ENST00000485727
• ENSP00000418002
• ENST00000488653
• ENSP00000420180
• ENST00000489746
• ENSP00000418403

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
cell line	0.7
transcription factor binding site profile	0.62
microRNA	0.61
tissue sample	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0