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Tbio
GLYR1
Putative oxidoreductase GLYR1

Protein Summary
Description
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321919
  • ENSP00000322716
  • ENSG00000140632
  • ENST00000436648
  • ENSP00000390276
  • ENST00000591451
  • ENSP00000468328

Symbol
  • HIBDL
  • NP60
  • NP60
  • BM045
  • HIBDL
  • N-PAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.84
disease perturbation
0.83
transcription factor perturbation
0.8
small molecule perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.83   (req: < 5)
View Publications
Gene RIFs: 0   (req: <= 3)
Antibodies: 96   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
EFO_0004340
1
1
1
75.8
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
EFO_0004340
1
75.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glyoxylate reductase 1 homolog
VGNC:9082
748328
Macaque
glyoxylate reductase 1 homolog
706933
Mouse
glyoxylate reductase 1 homolog (Arabidopsis)
MGI:1921272
74022
Rat
glyoxylate reductase 1 homolog
RGD:1309459
360477
Dog
glyoxylate reductase 1 homolog
VGNC:41284
479860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glyoxylate reductase 1 homolog
Macaque
glyoxylate reductase 1 homolog
Mouse
glyoxylate reductase 1 homolog (Arabidopsis)
Rat
glyoxylate reductase 1 homolog
Dog
glyoxylate reductase 1 homolog
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q49A26-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
histone binding
Inferred from Direct Assay (IDA)
UniProtKB
methylated histone binding
Inferred from Direct Assay (IDA)
UniProtKB
DNA binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
NAD binding
Inferred from Electronic Annotation (IEA)
InterPro
NADP binding
Inferred from Electronic Annotation (IEA)
InterPro
oxidoreductase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (99)
1 – 10 of 99
KDM1B
Tbio
Family: Epigenetic
Novelty: 0.02174039
p_int: 0.999998651
p_ni: 0.000001349
Score: 0.566
Data Source: BioPlex,STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.997868906
p_ni: 0.002131094
Data Source: BioPlex
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.985121707
p_ni: 0.014878293
Data Source: BioPlex
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.97401479
p_ni: 0.02598521
Score: 0.252
Data Source: BioPlex,STRINGDB
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.968486473
p_ni: 0.031513527
Data Source: BioPlex
RPL8
Tbio
Novelty: 0.01064076
p_int: 0.964211397
p_ni: 0.035788603
Score: 0.561
Data Source: BioPlex,STRINGDB
FNTB
Tchem
Family: Enzyme
Novelty: 0.07434994
p_int: 0.961462004
p_ni: 0.038183319
p_wrong: 0.000354677
Data Source: BioPlex
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.956444841
p_ni: 0.043555159
Score: 0.303
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00353077
p_int: 0.952648844
p_ni: 0.047351156
Score: 0.221
Data Source: BioPlex,STRINGDB
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.949494288
p_ni: 0.050505712
Data Source: BioPlex
Publication Statistics
PubMed Score  28.83

PubMed score by year
PubTator Score  9.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer