Tbio GLYR1 Putative oxidoreductase GLYR1

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Putative Oxidoreductase Glyr1

Protein Summary

Description

Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).

Uniprot Accession IDs

• Q49A26
• B4DL47
• C9JJ40
• C9JJ60
• Q5U632
• Q6P1Q2
• Q6V3W7
• Q9BTI1
• Q9BXK2

Gene Name

• GLYR1

Ensembl ID

• ENST00000321919
• ENSP00000322716
• ENSG00000140632
• ENST00000436648
• ENSP00000390276
• ENST00000591451
• ENSP00000468328

Symbol

• HIBDL
• NP60
• NP60
• BM045
• HIBDL
• N-PAC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
interacting protein	0.84
disease perturbation	0.83
transcription factor perturbation	0.8
small molecule perturbation	0.79

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.3   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.3   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (6)

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (11)

Functions (6)

Components (5)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
histone binding	Inferred from Direct Assay (IDA)	UniProtKB
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
NAD binding	Inferred from Electronic Annotation (IEA)	InterPro
NADP binding	Inferred from Electronic Annotation (IEA)	InterPro
oxidoreductase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (99)

Explore Interacting Targets

1 – 10 of 99

• See Interactions on String-DB

KDM1B

Tbio

Family: Epigenetic

Novelty: 0.03022771

p_int: 0.999998651

p_ni: 0.000001349

Score: 0.566

Data Source: BioPlex,STRINGDB

MAGEA1

Tbio

Novelty: 0.00581327

p_int: 0.997868906

p_ni: 0.002131094

Data Source: BioPlex

WDR46

Tdark

Novelty: 0.36421448

p_int: 0.985121707

p_ni: 0.014878293

Data Source: BioPlex

ZNF2

Tbio

Family: TF

Novelty: 0.01993056

p_int: 0.97401479

p_ni: 0.02598521

Score: 0.252

Data Source: BioPlex,STRINGDB

SERPINA12

Tbio

Novelty: 0.00636095

p_int: 0.968486473

p_ni: 0.031513527

Data Source: BioPlex

RPL8

Tbio

Novelty: 0.03315002

p_int: 0.964211397

p_ni: 0.035788603

Score: 0.561

Data Source: BioPlex,STRINGDB

FNTB

Tchem

Family: Enzyme

Novelty: 0.13625417

p_int: 0.961462004

p_ni: 0.038183319

p_wrong: 0.000354677

Data Source: BioPlex

RPL37A

Tbio

Novelty: 0.03125092

p_int: 0.956444841

p_ni: 0.043555159

Score: 0.303

Data Source: BioPlex,STRINGDB

NOP53

Tbio

Novelty: 0.00473377

p_int: 0.952648844

p_ni: 0.047351156

Score: 0.221

Data Source: BioPlex,STRINGDB

RPL28

Tbio

Novelty: 0.0322797

p_int: 0.949494288

p_ni: 0.050505712

Data Source: BioPlex

Publication Statistics

PubMed Score  63.30

PubMed score by year

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PubTator Score  9.7

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEM

1-70

IKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNM

70-140

GEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPV

140-210

KDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGS

210-280

GIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQG

280-350

IRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAM

350-420

GKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNIL

420-490

QGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

490-553

MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
NAD
Nucleus
Oxidoreductase
Phosphoprotein
Polymorphism