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Tdark
LONRF3
LON peptidase N-terminal domain and RING finger protein 3

Protein Summary
Description
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304778
  • ENSP00000307732
  • ENSG00000175556
  • ENST00000371628
  • ENSP00000360690
  • ENST00000481285
  • ENSP00000435426

Symbol
  • RNF127
  • RNF127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.91
PubMedID
0.72
molecular function
0.67
gene perturbation
0.65


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LON peptidase N-terminal domain and ring finger 3
VGNC:1366
473758
Macaque
LON peptidase N-terminal domain and ring finger 3
711202
Mouse
MGI:1921615
74365
Rat
RGD:1565451
298322
Dog
LON peptidase N-terminal domain and ring finger 3
VGNC:42736
100687354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LON peptidase N-terminal domain and ring finger 3
Macaque
LON peptidase N-terminal domain and ring finger 3
Mouse
Rat
Dog
LON peptidase N-terminal domain and ring finger 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q496Y0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (69)
1 – 10 of 69
AGO3
Tbio
Novelty:  0.01664154
p_int:  0.999997875
p_ni:  0.000001926
p_wrong:  1.99e-7
Score:  0.324
Data Source:  BioPlex,STRINGDB
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999980955
p_ni:  2.75e-7
p_wrong:  0.00001877
Score:  0.259
Data Source:  BioPlex,STRINGDB
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.999884541
p_ni:  0.000004155
p_wrong:  0.000111304
Score:  0.179
Data Source:  BioPlex,STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.728
Data Source:  STRINGDB
RNF32
Tdark
Novelty:  0.21111273
Score:  0.703
Data Source:  STRINGDB
TBC1D8
Tdark
Novelty:  0.40162575
Score:  0.694
Data Source:  STRINGDB
RNF149
Tdark
Family:  Enzyme
Novelty:  0.64503076
Score:  0.681
Data Source:  STRINGDB
ZCCHC18
Tdark
Novelty:  1.14005433
Score:  0.656
Data Source:  STRINGDB
MTMR8
Tbio
Family:  Enzyme
Novelty:  0.37417853
Score:  0.626
Data Source:  STRINGDB
PRODH2
Tbio
Family:  Enzyme
Novelty:  0.09377289
Score:  0.625
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.65

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer