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Tbio
SV2C
Synaptic vesicle glycoprotein 2C

Protein Summary
Description
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224). Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119). (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000502798
  • ENSP00000423541
  • ENSG00000122012

Symbol
  • KIAA1054
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell line
0.68
cell type or tissue
0.67
cellular component
0.63
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (75)
1 – 10 of 75
ABCC10
Tbio
Family:  Transporter
Novelty:  0.02281831
p_int:  0.942898818
p_ni:  0.048280844
p_wrong:  0.008820337
Score:  0.251
Data Source:  BioPlex,STRINGDB
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
p_int:  0.906303693
p_ni:  0.093694893
p_wrong:  0.000001414
Data Source:  BioPlex
EXTL3
Tbio
Family:  Enzyme
Novelty:  0.00714713
p_int:  0.86887287
p_ni:  0.13112713
Score:  0.189
Data Source:  BioPlex,STRINGDB
VANGL2
Tbio
Novelty:  0.00529796
p_int:  0.859229528
p_ni:  0.140770442
p_wrong:  3e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.840771348
p_ni:  0.158238575
p_wrong:  0.000990078
Score:  0.194
Data Source:  BioPlex,STRINGDB
UFD1
Tbio
Novelty:  0.01230296
p_int:  0.838851377
p_ni:  0.161148623
Score:  0.309
Data Source:  BioPlex,STRINGDB
SV2B
Tbio
Novelty:  0.02656002
Score:  0.825
Data Source:  STRINGDB
SV2A
Tclin
Novelty:  0.00127015
Score:  0.812
Data Source:  STRINGDB
GP2
Tbio
Novelty:  0.00126542
Score:  0.802
Data Source:  STRINGDB
MFSD11
Tdark
Novelty:  0.13167358
Score:  0.766
Data Source:  STRINGDB
Pathways (8)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Neurotoxicity of clostridium toxins
Reactome
Toxicity of botulinum toxin type A (BoNT/A)
Reactome
Toxicity of botulinum toxin type D (BoNT/D)
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Neurotoxicity of clostridium toxins
Toxicity of botulinum toxin type A (BoNT/A)
Toxicity of botulinum toxin type D (BoNT/D)
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
4
4
91.4
low density lipoprotein cholesterol measurement
1
4
4
68.5
red blood cell distribution width
2
1
2
64.9
reticulocyte count
2
2
3
63
platelet count
1
1
1
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
91.4
low density lipoprotein cholesterol measurement
4
68.5
red blood cell distribution width
2
64.9
reticulocyte count
3
63
platelet count
1
62.6
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptic vesicle glycoprotein 2C
VGNC:4187
471511
Macaque
synaptic vesicle glycoprotein 2C
706753
Mouse
MGI:1922459
75209
Rat
RGD:619718
29643
Dog
synaptic vesicle glycoprotein 2C
VGNC:47005
488943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptic vesicle glycoprotein 2C
Macaque
synaptic vesicle glycoprotein 2C
Mouse
Rat
Dog
synaptic vesicle glycoprotein 2C
Publication Statistics
PubMed Score 36.18
PubMed score by year
PubTator Score 15.53
PubTator score by year