Tbio CD300E CMRF35-like molecule 2

Protein Summary

Description

Probably acts as an activating receptor. This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q496F6
• B4DNS1
• Q7Z7I3
• CLM-2

Gene Name

• CD300E

Ensembl ID

• ENST00000392619
• ENSP00000376395
• ENSG00000186407

Symbol

• CD300LE
• CLM2
• CMRF35A5
• IREM2
• CLM2
• CLM-2
• IREM2
• PIgR2
• IREM-2
• PIgR-2
• CD300LE
• CMRF35-A5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
tissue	0.57
microRNA	0.52
tissue sample	0.51
cell line	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.33   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.33   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0