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Tbio
CD300E
CMRF35-like molecule 2

Protein Summary
Description
Probably acts as an activating receptor. This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392619
  • ENSP00000376395
  • ENSG00000186407

Symbol
  • CD300LE
  • CLM2
  • CMRF35A5
  • IREM2
  • CLM2
  • CLM-2
  • IREM2
  • PIgR2
  • IREM-2
  • PIgR-2
  • CD300LE
  • CMRF35-A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
tissue
0.57
microRNA
0.52
tissue sample
0.51
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
P10314
Tbio
Novelty:  0.00270731
p_int:  0.968351558
p_ni:  0.031648442
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.938679917
p_ni:  0.060788856
p_wrong:  0.000531227
Score:  0.189
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.920829823
p_ni:  0.079169945
p_wrong:  2.32e-7
Data Source:  BioPlex
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.909826218
p_ni:  0.09017378
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
ATF6
Tbio
Family:  TF
Novelty:  0.00149266
p_int:  0.81231917
p_ni:  0.18768083
Score:  0.243
Data Source:  BioPlex,STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.994
Data Source:  Reactome,STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.648
Data Source:  STRINGDB
CD247
Tbio
Novelty:  0.00217194
Score:  0.565
Data Source:  STRINGDB
CHST4
Tbio
Family:  Enzyme
Novelty:  0.02345662
Score:  0.525
Data Source:  STRINGDB
LILRA1
Tbio
Novelty:  0.17371827
Score:  0.503
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
DAP12 interactions
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
3
6
97.1
monocyte count
2
2
2
84.9
lymphocyte count
4
4
4
84.3
myeloid white cell count
2
2
2
82.1
fibrinogen measurement
4
2
3
6.5
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
97.1
monocyte count
2
84.9
lymphocyte count
4
84.3
myeloid white cell count
2
82.1
fibrinogen measurement
3
6.5
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CD300e molecule [Source:HGNC Symbol;Acc:HGNC:28874]
Mouse
MGI:2387602
217306
Rat
RGD:1585137
690076
Dog
CD300e molecule
VGNC:38947
100686403
Horse
CD300e molecule
VGNC:52361
106780850
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CD300e molecule [Source:HGNC Symbol;Acc:HGNC:28874]
Mouse
Rat
Dog
CD300e molecule
Horse
CD300e molecule
Publication Statistics
PubMed Score 30.33
PubMed score by year
PubTator Score 5.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title