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Tdark
TRIM60
Tripartite motif-containing protein 60

Protein Summary
Description
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341062
  • ENSP00000343765
  • ENSG00000176979
  • ENST00000508504
  • ENSP00000426496
  • ENST00000512596
  • ENSP00000421142
  • ENST00000647760
  • ENSP00000497401

Symbol
  • RNF129
  • RNF33
  • RNF33
  • RNF129
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell type or tissue
0.72
cell line
0.58
tissue
0.57
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
ZNF736
Tdark
Family:  TF
Novelty:  4.60487288
Score:  0.699
Data Source:  STRINGDB
FAM218A
Tdark
Novelty:  10.69354839
Score:  0.588
Data Source:  STRINGDB
KIF3B
Tbio
Novelty:  0.01877656
Score:  0.574
Data Source:  STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
Score:  0.539
Data Source:  STRINGDB
TRIM42
Tdark
Novelty:  0.21068414
Score:  0.537
Data Source:  STRINGDB
TMEM192
Tbio
Novelty:  0.30699087
Score:  0.513
Data Source:  STRINGDB
TRIM36
Tbio
Family:  Enzyme
Novelty:  0.06724803
Score:  0.481
Data Source:  STRINGDB
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.473
Data Source:  STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
Score:  0.469
Data Source:  STRINGDB
PTPN3
Tbio
Family:  Enzyme
Novelty:  0.02390509
Score:  0.467
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
1
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 60
VGNC:12870
471335
Macaque
tripartite motif-containing protein 60
704575
Mouse
MGI:2387430
234329
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 60
Macaque
tripartite motif-containing protein 60
Mouse
Publication Statistics
PubMed Score 3.94
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title