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Tchem
SLC36A2
Proton-coupled amino acid transporter 2

Protein Summary
Description
Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity). This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335244
  • ENSP00000334223
  • ENSG00000186335

Symbol
  • PAT2
  • TRAMD1
  • PAT2
  • TRAMD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
gene perturbation
0.71
cellular component
0.65
small molecule perturbation
0.61
microRNA
0.56


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 36 member 2
VGNC:13590
462200
Mouse
MGI:1891430
246049
Rat
RGD:620492
246235
Dog
solute carrier family 36 member 2
VGNC:46383
489174
Horse
solute carrier family 36 member 2
VGNC:23181
100071541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 36 member 2
Mouse
Rat
Dog
solute carrier family 36 member 2
Horse
solute carrier family 36 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q495M3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Proton-coupled neutral amino acid transporters
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)
Disease
Disorders of transmembrane transporters
Proton-coupled neutral amino acid transporters
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (53)
1 – 10 of 53
SLC6A20
Tbio
Family: Transporter
Novelty: 0.01435823
Score: 0.907
Data Source: STRINGDB
SLC6A19
Tchem
Family: Transporter
Novelty: 0.01581031
Score: 0.907
Data Source: STRINGDB
SLC6A18
Tbio
Family: Transporter
Novelty: 0.1198606
Score: 0.906
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.829
Data Source: STRINGDB
SLC13A2
Tbio
Family: Transporter
Novelty: 0.01020451
Score: 0.726
Data Source: STRINGDB
SLC6A16
Tdark
Family: Transporter
Novelty: 0.53896756
Score: 0.716
Data Source: STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
Score: 0.642
Data Source: STRINGDB
IGFBP1
Tchem
Novelty: 0.0006975
Score: 0.627
Data Source: STRINGDB
TNFSF11
Tclin
Novelty: 0.00018328
Score: 0.626
Data Source: STRINGDB
P2RX5
Tchem
Family: IC
Novelty: 0.01591178
Score: 0.586
Data Source: STRINGDB
Publication Statistics
PubMed Score  78.62

PubMed score by year
PubTator Score  24.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer