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Tbio
RNF212
Probable E3 SUMO-protein ligase RNF212

Protein Summary
Description
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333673
  • ENSP00000327481
  • ENSG00000178222
  • ENST00000382968
  • ENSP00000372428
  • ENST00000433731
  • ENSP00000389709
  • ENST00000511620
  • ENSP00000426115

Symbol
  • ZHP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.89
tissue sample
0.69
disease
0.62
cell type or tissue
0.52
tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
recombination rate
2
2
0
79.5
97.2
heel bone mineral density
1
1
1
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
recombination rate
0
79.5
97.2
heel bone mineral density
1
86.3
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein sumoylation.
Name
Explore in Pharos
Explore in Source
Protein modification; protein sumoylation.
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
MSH4
Tbio
Novelty: 0.00838156
Score: 0.873
Data Source: STRINGDB
CCNB1IP1
Tbio
Family: Enzyme
Novelty: 0.0425612
Score: 0.863
Data Source: STRINGDB
SPO11
Tbio
Novelty: 0.00273994
Score: 0.855
Data Source: STRINGDB
MSH5
Tbio
Novelty: 0.0109825
Score: 0.839
Data Source: STRINGDB
CNTD1
Tbio
Novelty: 0.22055841
Score: 0.838
Data Source: STRINGDB
PRDM9
Tbio
Family: TF; Epigenetic
Novelty: 0.0051717
Score: 0.768
Data Source: STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.747
Data Source: STRINGDB
SIX6OS1
Tdark
Novelty: 0.49801014
Score: 0.728
Data Source: STRINGDB
TEX11
Tbio
Novelty: 0.04868648
Score: 0.726
Data Source: STRINGDB
MUS81
Tbio
Family: Enzyme
Novelty: 0.00532122
Score: 0.702
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.78

PubMed score by year
PubTator Score  6.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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